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dc.contributor.authorNakhaee, S.
dc.contributor.authorFarrokhfall, K.
dc.contributor.authorMiri-Moghaddam, E.
dc.contributor.authorFoadoddini, M.
dc.contributor.authorAskari, M.
dc.contributor.authorMehrpour, O.
dc.date.accessioned2021-11-29T20:25:00Z
dc.date.available2021-11-29T20:25:00Z
dc.date.issued2021
dc.identifier.citationNakhaee, S., Farrokhfall, K., Miri-Moghaddam, E., Foadoddini, M., Askari, M., & Mehrpour, O. (2021). The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication. BMC Pharmacology and Toxicology.
dc.identifier.issn2050-6511
dc.identifier.doi10.1186/s40360-021-00532-8
dc.identifier.urihttp://hdl.handle.net/10150/662400
dc.description.abstractBackground: Tramadol is a widely used synthetic opioid for moderate to severe pain. Some studies have shown that tramadol can increase oxidative stress in different tissues of the body. Quercetin is also a substance with various biological effects, including antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, and cardioprotective activities. The current investigation aimed at determining the effects of quercetin, with or without naloxone, on tramadol intoxication. Methods: This study was performed on 30 male Wistar rats divided into five groups: Group I) control group: intraperitoneal injections of normal saline 0.9% for 14 days; Group II) tramadol: 25 mg/kg for 14 days, and then a 50 mg/kg acute dose injection on the last day; Group III) acute quercetin (single dose): tramadol injection as with the second group plus 100 mg/kg of quercetin on the last day; Group IV) chronic quercetin: tramadol injection similar to the second group plus quercetin 100 mg/kg for 14 days; Group V) quercetin plus naloxone: tramadol injection similar to the second group plus injection of quercetin 100 mg/kg + intravenous naloxone 2 mg/kg on the last day, followed by a 4 mg/kg/h injection of naloxone for six hours. The rats were monitored for six hours on the last day, relating to the number and severity of seizures. Finally, the samples were prepared for biochemical investigation of the serum level of oxidative stress markers (MDA, SOD, NOx), inflammatory factors (IL-6, TNF-α), biochemical parameters (ALT, AST, creatinine, glucose) and hematological assay. The liver, heart, kidney, cortex, cerebellum, and adrenal tissues were collected to investigate the redox state. Results: None of the treatments had positive effects on the number and severity of seizures. Chronic administration of quercetin led to alteration of some blood parameters, including reduced hemoglobin level and elevated platelet counts. Acute on chronic tramadol administration resulted in a significant rise in AST, where different treatments failed to reduce their levels down to the control group. Conclusion: chronic administration of quercetin showed decreased oxidative/nitrosative stress in the liver, kidney, adrenal, and heart tissues. Quercetin plus naloxone decreased oxidative stress in the heart and adrenal tissues, but adverse effects on the brain cortex and hepatic function. Single-dose quercetin reduced cardiac oxidative stress. © 2021, The Author(s).
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.rightsCopyright © The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAcute on chronic
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectQuercetin
dc.subjectTramadol
dc.titleThe effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication
dc.typeArticle
dc.typetext
dc.contributor.departmentMel and Enid Zuckerman College of Public Health, University of Arizona
dc.identifier.journalBMC Pharmacology and Toxicology
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleBMC Pharmacology and Toxicology
refterms.dateFOA2021-11-29T20:25:00Z


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Copyright © The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s). 2021. This article is licensed under a Creative Commons Attribution 4.0 International License.