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dc.contributor.authorNgonghala, C.N.
dc.contributor.authorKnitter, J.R.
dc.contributor.authorMarinacci, L.
dc.contributor.authorBonds, M.H.
dc.contributor.authorGumel, A.B.
dc.date.accessioned2021-11-29T20:25:21Z
dc.date.available2021-11-29T20:25:21Z
dc.date.issued2021
dc.identifier.citationNgonghala, C. N., Knitter, J. R., Marinacci, L., Bonds, M. H., & Gumel, A. B. (2021). Assessing the impact of widespread respirator use in curtailing COVID-19 transmission in the USA. Royal Society Open Science.
dc.identifier.issn2054-5703
dc.identifier.doi10.1098/rsos.210699
dc.identifier.urihttp://hdl.handle.net/10150/662432
dc.description.abstractDynamic models are used to assess the impact of three types of face masks (cloth masks, surgical/procedure masks and respirators) in controlling the COVID-19 pandemic in the USA. We showed that the pandemic would have failed to establish in the USA if a nationwide mask mandate, based on using respirators with moderately high compliance, had been implemented during the first two months of the pandemic. The other mask types would fail to prevent the pandemic from becoming established. When mask usage compliance is low to moderate, respirators are far more effective in reducing disease burden. Using data from the third wave, we showed that the epidemic could be eliminated in the USA if at least 40% of the population consistently wore respirators in public. Surgical masks can also lead to elimination, but requires compliance of at least 55%. Daily COVID-19 mortality could be eliminated in the USA by June or July 2021 if 95% of the population opted for either respirators or surgical masks from the beginning of the third wave. We showed that the prospect of effective control or elimination of the pandemic using mask-based strategy is greatly enhanced if combined with other non-pharmaceutical interventions (NPIs) that significantly reduce the baseline community transmission. By slightly modifying the model to include the effect of a vaccine against COVID-19 and waning vaccine-derived and natural immunity, this study shows that the waning of such immunity could trigger multiple new waves of the pandemic in the USA. The number, severity and duration of the projected waves depend on the quality of mask type used and the level of increase in the baseline levels of other NPIs used in the community during the onset of the third wave of the pandemic in the USA. Specifically, no severe fourth or subsequent wave of the pandemic will be recorded in the USA if surgical masks or respirators are used, particularly if the mask use strategy is combined with an increase in the baseline levels of other NPIs. This study further emphasizes the role of human behaviour towards masking on COVID-19 burden, and highlights the urgent need to maintain a healthy stockpile of highly effective respiratory protection, particularly respirators, to be made available to the general public in times of future outbreaks or pandemics of respiratory diseases that inflict severe public health and socio-economic burden on the population. © 2021 The Authors.
dc.language.isoen
dc.publisherRoyal Society Publishing
dc.rightsCopyright © 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectface masks and respirators
dc.subjectmathematical model
dc.subjectnon-pharmaceutical and pharmaceutical interventions
dc.subjectSARS-CoV-2
dc.subjectvaccines
dc.titleAssessing the impact of widespread respirator use in curtailing COVID-19 transmission in the USA
dc.typeArticle
dc.typetext
dc.contributor.departmentDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, College of Medicine, University of Arizona
dc.identifier.journalRoyal Society Open Science
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleRoyal Society Open Science
refterms.dateFOA2021-11-29T20:25:21Z


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Copyright © 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/.