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dc.contributor.authorAshar, Y.K.
dc.contributor.authorAndrews-Hanna, J.R.
dc.contributor.authorHalifax, J.
dc.contributor.authorDimidjian, S.
dc.contributor.authorWager, T.D.
dc.date.accessioned2021-11-29T20:25:27Z
dc.date.available2021-11-29T20:25:27Z
dc.date.issued2021
dc.identifier.citationAshar, Y. K., Andrews-Hanna, J. R., Halifax, J., Dimidjian, S., & Wager, T. D. (2021). Effects of compassion training on brain responses to suffering others. Social Cognitive and Affective Neuroscience.
dc.identifier.issn1749-5016
dc.identifier.pmid33948660
dc.identifier.doi10.1093/scan/nsab052
dc.identifier.urihttp://hdl.handle.net/10150/662436
dc.description.abstractCompassion meditation (CM) is a promising intervention for enhancing compassion, although its active ingredients and neurobiological mechanisms are not well-understood. To investigate these, we conducted a three-armed placebo-controlled randomized trial (N = 57) with longitudinal functional magnetic resonance imaging (fMRI). We compared a 4-week CM program delivered by smartphone application with (i) a placebo condition, presented to participants as the compassion-enhancing hormone oxytocin, and (ii) a condition designed to control for increased familiarity with suffering others, an element of CM which may promote compassion. At pre- and post-intervention, participants listened to compassion-eliciting narratives describing suffering others during fMRI. CM increased brain responses to suffering others in the medial orbitofrontal cortex (mOFC) relative to the familiarity condition, p < 0.05 family-wise error rate corrected. Among CM participants, individual differences in increased mOFC responses positively correlated with increased compassion-related feelings and attributions, r = 0.50, p = 0.04. Relative to placebo, the CM group exhibited a similar increase in mOFC activity at an uncorrected threshold of P < 0.001 and 10 contiguous voxels. We conclude that the mOFC, a region closely related to affiliative affect and motivation, is an important brain mechanism of CM. Effects of CM on mOFC function are not explained by familiarity effects and are partly explained by placebo effects. © 2021 The Author(s) 2021. Published by Oxford University Press.
dc.language.isoen
dc.publisherOxford University Press
dc.rightsCopyright © The Author(s) 2021. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectburnout
dc.subjectcompassion training
dc.subjectempathy
dc.subjectmindfulness
dc.subjectplacebo
dc.titleEffects of compassion training on brain responses to suffering others
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Psychology, University of Arizona
dc.identifier.journalSocial Cognitive and Affective Neuroscience
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleSocial Cognitive and Affective Neuroscience
refterms.dateFOA2021-11-29T20:25:27Z


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Copyright © The Author(s) 2021. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2021. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).