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    Promoting Patient Safety During Intranasal Esketamine Administration

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    Author
    Guthrie, Mikael
    Issue Date
    2021
    Keywords
    depression
    esketamine
    IET
    ketamine
    REMS
    trauma
    Advisor
    Edmund, Sara
    
    Metadata
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Purpose: Strengthen La Frontera psychiatric provider and nursing staff knowledge regarding intranasal esketamine therapy, promote safety of intranasal eskatamine administration at La Frontera, and increase intent to use a formal safety protocol during administration and patient monitoring. Background: Treatment-resistant depression affects nearly one-third of individuals diagnosed with major depressive disorder. Intranasal esketamine therapy is a new treatment available for individuals with treatment-resistant depression, and carries a significant risk profile, requiring administration and monitoring at designated clinics authorized to prescribe it. Presently, no standardized safety protocol exists to monitor patients during esketamine therapy sessions. Methods: This was a quality improvement project. The invited participants were 13 psychiatric providers and registered nurses at La Frontera in Phoenix, Arizona. The project design was an asynchronous educational PowerPoint presentation with pre- and post-presentation surveys delivered through Qualtrics via emailed hyperlink. Participation was voluntary and anonymous. Results: One invitee (n=1) participated in the intervention and submitted completed surveys. The sole participant indicated in their survey responses that their knowledge of intranasal esketamine therapy was enhanced. They further indicated a strong intent to use the proposed safety protocol were it to be implemented by La Frontera. 10 Conclusions: While the survey results indicate the participants’ knowledge of intranasal esketamine and intent to use a safety protocol was enhanced by the educational presentation, the small number of participants (n=1) made it very difficult to extrapolate any meaningful data regarding whether or not psychiatric providers and nurses at La Frontera found the educational presentation useful or informative, or whether a general sentiment in favor of adopting the safety protocol exists among La Frontera staff. This project provides an initial foundation for future research regarding the adoption of a standardized safety protocol among outpatient clinics administering intranasal esketamine. Further inquiries could help identify and overcome potential barriers, including alternative implementation strategies as well as modifications to the safety protocol to promote brevity.
    Type
    text
    Electronic Dissertation
    Degree Name
    D.N.P.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Nursing
    Degree Grantor
    University of Arizona
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