Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes
AuthorFranco, Mario E E
Wisecaver, Jennifer H
Arnold, A Elizabeth
Slot, Jason C
Moore, Lillian P
Eastman, Katharine E
Mondo, Stephen J
Hayes, Richard D
Eastwood, Daniel C
Hamelin, Richard C
Grigoriev, Igor V
U'Ren, Jana M
AffiliationBIO5 Institute and Department of Biosystems Engineering, The University of Arizona
School of Plant Sciences, The University of Arizona
Department of Ecology and Evolutionary Biology, University of Arizona
MetadataShow full item record
PublisherJohn Wiley and Sons Inc
CitationFranco, M. E. E., Wisecaver, J. H., Arnold, A. E., Ju, Y.-M., Slot, J. C., Ahrendt, S., Moore, L. P., Eastman, K. E., Scott, K., Konkel, Z., Mondo, S. J., Kuo, A., Hayes, R. D., Haridas, S., Andreopoulos, B., Riley, R., LaButti, K., Pangilinan, J., Lipzen, A., … U’Ren, J. M. (2021). Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes. New Phytologist.
JournalThe New Phytologist
Rights© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
Abstract- Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. - Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. - All genomes contain hyperabundant SMGCs; however, Xylariaceae have increased num- bers of gene duplications, horizontal gene transfers (HGTs) and SMGCs. Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. - Our results suggest that, as host and substrate generalists, Xylariaceae endophytes experi- ence greater selection to diversify SMGCs compared with more ecologically specialised Hypoxylaceae species. Overall, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial sym- bioses to drive fungal metabolic diversity.
NotePublic domain article
VersionFinal published version
Except where otherwise noted, this item's license is described as © 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
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