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dc.contributor.authorFranco, Mario E E
dc.contributor.authorWisecaver, Jennifer H
dc.contributor.authorArnold, A Elizabeth
dc.contributor.authorJu, Yu-Ming
dc.contributor.authorSlot, Jason C
dc.contributor.authorAhrendt, Steven
dc.contributor.authorMoore, Lillian P
dc.contributor.authorEastman, Katharine E
dc.contributor.authorScott, Kelsey
dc.contributor.authorKonkel, Zachary
dc.contributor.authorMondo, Stephen J
dc.contributor.authorKuo, Alan
dc.contributor.authorHayes, Richard D
dc.contributor.authorHaridas, Sajeet
dc.contributor.authorAndreopoulos, Bill
dc.contributor.authorRiley, Robert
dc.contributor.authorLaButti, Kurt
dc.contributor.authorPangilinan, Jasmyn
dc.contributor.authorLipzen, Anna
dc.contributor.authorAmirebrahimi, Mojgan
dc.contributor.authorYan, Juying
dc.contributor.authorAdam, Catherine
dc.contributor.authorKeymanesh, Keykhosrow
dc.contributor.authorNg, Vivian
dc.contributor.authorLouie, Katherine
dc.contributor.authorNorthen, Trent
dc.contributor.authorDrula, Elodie
dc.contributor.authorHenrissat, Bernard
dc.contributor.authorHsieh, Huei-Mei
dc.contributor.authorYouens-Clark, Ken
dc.contributor.authorLutzoni, François
dc.contributor.authorMiadlikowska, Jolanta
dc.contributor.authorEastwood, Daniel C
dc.contributor.authorHamelin, Richard C
dc.contributor.authorGrigoriev, Igor V
dc.contributor.authorU'Ren, Jana M
dc.date.accessioned2022-01-13T21:09:05Z
dc.date.available2022-01-13T21:09:05Z
dc.date.issued2021-12-07
dc.identifier.citationFranco, M. E. E., Wisecaver, J. H., Arnold, A. E., Ju, Y.-M., Slot, J. C., Ahrendt, S., Moore, L. P., Eastman, K. E., Scott, K., Konkel, Z., Mondo, S. J., Kuo, A., Hayes, R. D., Haridas, S., Andreopoulos, B., Riley, R., LaButti, K., Pangilinan, J., Lipzen, A., … U’Ren, J. M. (2021). Ecological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytes. New Phytologist.en_US
dc.identifier.issn0028-646X
dc.identifier.pmid34797921
dc.identifier.doi10.1111/nph.17873
dc.identifier.urihttp://hdl.handle.net/10150/662893
dc.description.abstract- Although secondary metabolites are typically associated with competitive or pathogenic interactions, the high bioactivity of endophytic fungi in the Xylariales, coupled with their abundance and broad host ranges spanning all lineages of land plants and lichens, suggests that enhanced secondary metabolism might facilitate symbioses with phylogenetically diverse hosts. - Here, we examined secondary metabolite gene clusters (SMGCs) across 96 Xylariales genomes in two clades (Xylariaceae s.l. and Hypoxylaceae), including 88 newly sequenced genomes of endophytes and closely related saprotrophs and pathogens. We paired genomic data with extensive metadata on endophyte hosts and substrates, enabling us to examine genomic factors related to the breadth of symbiotic interactions and ecological roles. - All genomes contain hyperabundant SMGCs; however, Xylariaceae have increased num- bers of gene duplications, horizontal gene transfers (HGTs) and SMGCs. Enhanced metabolic diversity of endophytes is associated with a greater diversity of hosts and increased capacity for lignocellulose decomposition. - Our results suggest that, as host and substrate generalists, Xylariaceae endophytes experi- ence greater selection to diversify SMGCs compared with more ecologically specialised Hypoxylaceae species. Overall, our results provide new evidence that SMGCs may facilitate symbiosis with phylogenetically diverse hosts, highlighting the importance of microbial sym- bioses to drive fungal metabolic diversity.en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.rights© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. This article has been contributed to by US Government employees and their work is in the public domain in the USA.en_US
dc.rights.urihttps://creativecommons.org/publicdomain/mark/1.0/en_US
dc.subjectAscomycotaen_US
dc.subjectXylarialesen_US
dc.subjectendophyteen_US
dc.subjectplant-fungal interactionsen_US
dc.subjectSaprotrophen_US
dc.subjectspecialised metabolismen_US
dc.subjectsymbiosisen_US
dc.subjecttrophic modeen_US
dc.titleEcological generalism drives hyperdiversity of secondary metabolite gene clusters in xylarialean endophytesen_US
dc.typeArticleen_US
dc.identifier.eissn1469-8137
dc.contributor.departmentBIO5 Institute and Department of Biosystems Engineering, The University of Arizonaen_US
dc.contributor.departmentSchool of Plant Sciences, The University of Arizonaen_US
dc.contributor.departmentDepartment of Ecology and Evolutionary Biology, University of Arizonaen_US
dc.identifier.journalThe New Phytologisten_US
dc.description.notePublic domain articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleThe New phytologist
dc.source.volume233
dc.source.issue3
dc.source.beginpage1317
dc.source.endpage1330
refterms.dateFOA2022-01-13T21:09:07Z
dc.source.countryEngland


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© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Except where otherwise noted, this item's license is described as © 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. This article has been contributed to by US Government employees and their work is in the public domain in the USA.