Show simple item record

dc.contributor.authorKhan, S.M.
dc.contributor.authorFarland, L.V.
dc.contributor.authorCatalfamo, C.J.
dc.contributor.authorAusthof, E.
dc.contributor.authorBell, M.L.
dc.contributor.authorChen, Z.
dc.contributor.authorCordova-Marks, F.
dc.contributor.authorErnst, K.C.
dc.contributor.authorGarcia-Filion, P.
dc.contributor.authorHeslin, K.M.
dc.contributor.authorHoskinson, J.
dc.contributor.authorJehn, M.L.
dc.contributor.authorJoseph, E.C.S.
dc.contributor.authorKelley, C.P.
dc.contributor.authorKlimentidis, Y.
dc.contributor.authorRusso Carroll, S.
dc.contributor.authorKohler, L.N.
dc.contributor.authorPogreba-Brown, K.
dc.contributor.authorJacobs, E.T.
dc.date.accessioned2022-03-17T01:57:00Z
dc.date.available2022-03-17T01:57:00Z
dc.date.issued2022
dc.identifier.citationKhan, S. M., Farland, L. V., Catalfamo, C. J., Austhof, E., Bell, M. L., Chen, Z., Cordova-Marks, F., Ernst, K. C., Garcia-Filion, P., Heslin, K. M., Hoskinson, J., Jehn, M. L., Joseph, E. C. S., Kelley, C. P., Klimentidis, Y., Russo Carroll, S., Kohler, L. N., Pogreba-Brown, K., & Jacobs, E. T. (2022). Elucidating symptoms of COVID-19 illness in the Arizona CoVHORT: A longitudinal cohort study. BMJ Open.
dc.identifier.issn2044-6055
dc.identifier.pmid35039294
dc.identifier.doi10.1136/bmjopen-2021-053403
dc.identifier.urihttp://hdl.handle.net/10150/663583
dc.description.abstractObjective To elucidate the symptoms of laboratory-confirmed COVID-19 cases as compared with laboratory-confirmed negative individuals and to the untested general population among all participants who reported symptoms within a large prospective cohort study. Setting and design This work was conducted within the framework of the Arizona CoVHORT, a longitudinal prospective cohort study conducted among Arizona residents. Participants Eligible participants were any individual living in Arizona and were recruited from across Arizona via COVID-19 case investigations, participation in testing studies and a postcard mailing effort. Primary and secondary outcome measures The primary outcome measure was a comparison of the type and frequency of symptoms between COVID-19-positive cases, tested but negative individuals and the general untested population who reported experiencing symptoms consistent with COVID-19. Results Of the 1335 laboratory-confirmed COVID-19 cases, 180 (13.5%) reported having no symptoms. Of those that did report symptoms, the most commonly reported were fatigue (82.2%), headache (74.6%), aches, pains or sore muscles (66.3%), loss of taste or smell (62.8) and cough (61.9%). In adjusted logistic regression models, COVID-19-positive participants were more likely than negative participants to experience loss of taste and smell (OR 12.1; 95% CI 9.6 to 15.2), bone or nerve pain (OR 3.0; 95% CI 2.2 to 4.1), headache (OR 2.6; 95% CI 2.2 to 3.2), nausea (OR 2.4; 95% CI 1.9 to 3.1) or diarrhoea (OR 2.1; 95% CI 1.7 to 2.6). Fatigue (82.9) and headache (74.9) had the highest sensitivities among symptoms, while loss of taste or smell (87.2) and bone or nerve pain (92.9) had the high specificities among significant symptoms associated with COVID-19. Conclusion When comparing confirmed COVID-19 cases with either confirmed negative or untested participants, the pattern of symptoms that discriminates SARS-CoV-2 infection from those arising from other potential circulating pathogens may differ from general reports of symptoms among cases alone. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rightsCopyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCOVID-19
dc.subjectepidemiology
dc.subjectinfectious diseases
dc.titleElucidating symptoms of COVID-19 illness in the Arizona CoVHORT: A longitudinal cohort study
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Epidemiology and Biostatistics, The University of Arizona
dc.contributor.departmentThe University of Arizona Cancer Center
dc.contributor.departmentDepartment of Health Promotion Sciences, The University of Arizona
dc.contributor.departmentDepartment of Biomedical Informatics, The University of Arizona
dc.contributor.departmentDepartment of Community, Environment, and Policy, The University of Arizona
dc.contributor.departmentNative Nations Institute at the Udall Center for Studies in Public Policy, The University of Arizona
dc.identifier.journalBMJ Open
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleBMJ Open
refterms.dateFOA2022-03-17T01:57:00Z


Files in this item

Thumbnail
Name:
e053403.full.pdf
Size:
280.1Kb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record

Copyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC.
Except where otherwise noted, this item's license is described as Copyright © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC.