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dc.contributor.authorWalker, A.L.
dc.contributor.authorUeda, Y.
dc.contributor.authorCrofton, A.E.
dc.contributor.authorHarris, S.P.
dc.contributor.authorStern, J.A.
dc.date.accessioned2022-03-17T01:57:17Z
dc.date.available2022-03-17T01:57:17Z
dc.date.issued2022
dc.identifier.citationWalker, A. L., Ueda, Y., Crofton, A. E., Harris, S. P., & Stern, J. A. (2022). Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy. Scientific Reports.
dc.identifier.issn2045-2322
dc.identifier.pmid35121794
dc.identifier.doi10.1038/s41598-022-05999-x
dc.identifier.urihttp://hdl.handle.net/10150/663611
dc.description.abstractThe utility of ambulatory electrocardiography (AECG) to evaluate cats with subclinical hypertrophic cardiomyopathy (HCM) for arrhythmias and heart rate variability (HRV) is not well defined but may provide information regarding risk stratification. This prospective study used AECG to evaluate ectopy and HRV in subclinical HCM cats compared to healthy controls and is the first to implement a pharmacologic cardiac stress test. Twenty-three purpose-bred, Maine coon cross cats (16 HCM, 7 control) underwent 48-h of continuous AECG. Terbutaline (0.2-0.3 mg/kg) was administered orally at 24 and 36 h. Heart rate, ectopy frequency and complexity and HRV parameters, including standard deviation of normal R-R intervals (SDNN), were compared pre-terbutaline and post-terbutaline and across phenotype, genotype and sex. Genotype for an HCM-causative mutation was significantly associated with the frequency of supraventricular (P = 0.033) and ventricular (P = 0.026) ectopy across all cats. Seven HCM cats and zero healthy cats had a sinus arrhythmia. Mean heart rate was significantly higher post-terbutaline (p < 0.0001). HCM cats had significantly greater HRV compared to controls (SDNN: p = 0.0006). Male cats had significantly higher HRV (SDNN: p = 0.0001) and lower mean heart rates (p = 0.0001). HRV decreased post-terbutaline (SDNN: p = 0.0008) and changes in HRV observed between sexes were attenuated by terbutaline. © 2022. The Author(s).
dc.language.isoen
dc.publisherNature Research
dc.rightsCopyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAmbulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Cellular and Molecular Medicine, University of Arizona
dc.identifier.journalScientific reports
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleScientific reports
refterms.dateFOA2022-03-17T01:57:17Z


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Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.