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dc.contributor.authorPowell, D.A.
dc.contributor.authorShubitz, L.F.
dc.contributor.authorButkiewicz, C.D.
dc.contributor.authorTrinh, H.T.
dc.contributor.authorDonovan, F.M.
dc.contributor.authorFrelinger, J.A.
dc.contributor.authorGalgiani, J.N.
dc.date.accessioned2022-03-18T00:03:50Z
dc.date.available2022-03-18T00:03:50Z
dc.date.issued2022
dc.identifier.citationPowell, D. A., Shubitz, L. F., Butkiewicz, C. D., Trinh, H. T., Donovan, F. M., Frelinger, J. A., & Galgiani, J. N. (2022). TNFα Blockade Inhibits Both Initial and Continued Control of Pulmonary Coccidioides. Frontiers in Cellular and Infection Microbiology.
dc.identifier.issn2235-2988
dc.identifier.pmid35174101
dc.identifier.doi10.3389/fcimb.2021.796114
dc.identifier.urihttp://hdl.handle.net/10150/663650
dc.description.abstractTumor necrosis factor alpha (TNFα) is a pluripotent cytokine that is important in many infections, though its role in Coccidioides infection remains poorly understood. The need to understand TNFα in Coccidioides infection has increased recently with the widespread use of TNFα inhibitors for a wide variety of autoimmune conditions. Here, we couple the newly developed Coccidioides infection model using strain Cp1038 and C57BL/6 × DBA/2J F1 (B6D2F1) mice. B6D2F1 mice develop long-lasting control of Cp1038. Treatment of B6D2F1 mice with anti-TNFα antibodies permits significant fungal proliferation and death. Additionally, we show that antibody treatment limited to the first 2 weeks of infection was sufficient to induce this same loss of fungal control. Importantly, anti-TNFα antibody treatment initiated after fungal control leads to a loss of host control. These results highlight the importance of TNFα in both the initial control of murine Coccidioides and ongoing suppression of the fungal disease. Copyright © 2022 Powell, Shubitz, Butkiewicz, Trinh, Donovan, Frelinger and Galgiani.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rightsCopyright © 2022 Powell, Shubitz, Butkiewicz, Trinh, Donovan, Frelinger and Galgiani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbiological response modifiers
dc.subjectCoccidioides
dc.subjectpathogenesis
dc.subjectTNFα
dc.subjectvalley fever
dc.titleTNFα Blockade Inhibits Both Initial and Continued Control of Pulmonary Coccidioides
dc.typeArticle
dc.typetext
dc.contributor.departmentValley Fever Center for Excellence, University of Arizona
dc.contributor.departmentDepartment of Immunobiology, University of Arizona
dc.contributor.departmentDepartment of Medicine, University of Arizona
dc.identifier.journalFrontiers in Cellular and Infection Microbiology
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleFrontiers in Cellular and Infection Microbiology
refterms.dateFOA2022-03-18T00:03:50Z


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Copyright © 2022 Powell, Shubitz, Butkiewicz, Trinh, Donovan, Frelinger and Galgiani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2022 Powell, Shubitz, Butkiewicz, Trinh, Donovan, Frelinger and Galgiani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).