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dc.contributor.authorMartinez, J.A.
dc.contributor.authorTaljanovic, M.S.
dc.contributor.authorZuniga, A.A.N.
dc.contributor.authorWertheim, B.C.
dc.contributor.authorRoe, D.J.
dc.contributor.authorEhsani, S.
dc.contributor.authorJiralerspong, S.
dc.contributor.authorSegar, J.
dc.contributor.authorChalasani, P.
dc.date.accessioned2022-03-18T00:04:01Z
dc.date.available2022-03-18T00:04:01Z
dc.date.issued2022
dc.identifier.citationMartinez, J. A., Taljanovic, M. S., Zuniga, A. A. N., Wertheim, B. C., Roe, D. J., Ehsani, S., Jiralerspong, S., Segar, J., & Chalasani, P. (2022). Feasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias. Journal of Clinical Medicine.
dc.identifier.issn2077-0383
dc.identifier.doi10.3390/jcm11041067
dc.identifier.urihttp://hdl.handle.net/10150/663668
dc.description.abstractAromatase inhibitor-induced arthralgia (AIA) comprises significant, activity-limiting mus-culoskeletal symptoms, including joint pain, myalgia, and joint stiffness. We conducted a prospective feasibility study in postmenopausal women diagnosed with early-stage (0–3) hormone receptor positive (HR+) breast cancer who were candidates for treatment with adjuvant AI therapy (n = 16). Tendons of the hands and wrists and the median nerve were imaged using gray-scale and power Doppler ultrasound (US) and US SWE. Arthralgia symptoms were evaluated using the Breast Cancer Prevention Trial (BCPT) Symptom Checklist musculoskeletal subscale (MS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain and stiffness subscales. At baseline, there were significant differences in the SW velocities of tendons between dominant and nondominant hands. Increased velocity in 2 of 6 tendons and the median nerve was associated with greater pain at baseline, whereas slower velocity of the extensor digitorum tendon (suggesting decreased stiffness) was associated with a higher WOMAC stiffness score. Increased SW velocity (suggestive of increased stiffness) at baseline in the abductor pollicis longus tendon was associated with a worsening of all three pain and stiffness measures by 6 months. Future studies should evaluate SWE scores related to AIA outcomes in a larger sample size. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI
dc.rightsCopyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAromatase inhibitors
dc.subjectAromatase inhibitor–induced arthralgia (AIA)
dc.subjectArthralgia
dc.subjectBreast cancer
dc.subjectJoint pain
dc.subjectShear wave elastography
dc.subjectStiffness
dc.subjectUltrasound
dc.titleFeasibility Trial to Evaluate Tendon Stiffness Obtained from Shear Wave Elastography Imaging as a Biomarker of Aromatase Inhibitor-Induced Arthralgias
dc.typeArticle
dc.typetext
dc.contributor.departmentThe University of Arizona Cancer Center
dc.contributor.departmentDepartment of Nutritional Sciences, University of Arizona
dc.contributor.departmentDepartment of Medical Imaging and Orthopaedic Surgery, University of Arizona
dc.contributor.departmentDepartment of Biomedical Engineering, University of Arizona
dc.contributor.departmentDepartment of Epidemiology and Biostatistics, University of Arizona
dc.contributor.departmentDepartment of Medicine, University of Arizona
dc.identifier.journalJournal of Clinical Medicine
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleJournal of Clinical Medicine
refterms.dateFOA2022-03-18T00:04:01Z


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Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).