Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease
Name:
s13148-022-01246-2.pdf
Size:
957.4Kb
Format:
PDF
Description:
Final Published Version
Affiliation
University of Arizona Cancer CenterDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona
Division of Hematology/Oncology, Department of Medicine, University of Arizona Cancer Center
Department of Pathology, College of Medicine, University of Arizona
Issue Date
2022Metadata
Show full item recordPublisher
BioMed Central LtdCitation
Vrba, L., Futscher, B. W., Oshiro, M., Watts, G. S., Menashi, E., Hu, C., Hammad, H., Pennington, D. R., Golconda, U., Gavini, H., Roe, D. J., Shroff, R. T., & Nelson, M. A. (2022). Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease. Clinical Epigenetics.Journal
Clinical EpigeneticsRights
Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
We tested the ability of a novel DNA methylation biomarker set to distinguish metastatic pancreatic cancer cases from benign pancreatic cyst patients and to monitor tumor dynamics using quantitative DNA methylation analysis of cell-free DNA (cfDNA) from blood samples. The biomarkers were able to distinguish malignant cases from benign disease with high sensitivity and specificity (AUC = 0.999). Furthermore, the biomarkers detected a consistent decline in tumor-derived cfDNA in samples from patients undergoing chemotherapy. The study indicates that our liquid biopsy assay could be useful for management of pancreatic cancer patients. © 2022, The Author(s).Note
Open access journalISSN
1868-7075PubMed ID
35193708Version
Final published versionScopus Count
Collections
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.