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dc.contributor.authorCené, C.W.
dc.contributor.authorLeng, X.I.
dc.contributor.authorFaraz, K.
dc.contributor.authorAllison, M.
dc.contributor.authorBreathett, K.
dc.contributor.authorBird, C.
dc.contributor.authorCoday, M.
dc.contributor.authorCorbie-Smith, G.
dc.contributor.authorForaker, R.
dc.contributor.authorIjioma, N.N.
dc.contributor.authorRosal, M.C.
dc.contributor.authorSealy-Jefferson, S.
dc.contributor.authorShippee, T.P.
dc.contributor.authorKroenke, C.H.
dc.date.accessioned2022-03-31T21:13:42Z
dc.date.available2022-03-31T21:13:42Z
dc.date.issued2022
dc.identifier.citationCené, C. W., Leng, X. I., Faraz, K., Allison, M., Breathett, K., Bird, C., Coday, M., Corbie-Smith, G., Foraker, R., Ijioma, N. N., Rosal, M. C., Sealy-Jefferson, S., Shippee, T. P., & Kroenke, C. H. (2022). Social Isolation and Incident Heart Failure Hospitalization in Older Women: Women’s Health Initiative Study Findings. Journal of the American Heart Association.
dc.identifier.issn2047-9980
dc.identifier.pmid35189692
dc.identifier.doi10.1161/JAHA.120.022907
dc.identifier.urihttp://hdl.handle.net/10150/663850
dc.description.abstractBackground The association of social isolation or lack of social network ties in older adults is unknown. This knowledge gap is important since the risk of heart failure (HF) and social isolation increase with age. The study examines whether social isolation is associated with incident HF in older women, and examines depressive symptoms as a potential mediator and age and race and ethnicity as effect modifiers. Methods and Results This study included 44 174 postmenopausal women of diverse race and ethnicity from the WHI (Women's Health Initiative) study who underwent annual assessment for HF adjudication from baseline enrollment (1993-1998) through 2018. We conducted a mediation analysis to examine depressive symptoms as a potential mediator and further examined effect modification by age and race and ethnicity. Incident HF requiring hospitalization was the main outcome. Social isolation was a composite variable based on marital/partner status, religious ties, and community ties. Depressive symptoms were assessed using CES-D (Center for Epidemiology Studies-Depression). Over a median follow-up of 15.0 years, we analyzed data from 36 457 women, and 2364 (6.5%) incident HF cases occurred; 2510 (6.9%) participants were socially isolated. In multivariable analyses adjusted for sociodemographic, behavioral, clinical, and general health/functioning; socially isolated women had a higher risk of incident HF than nonisolated women (HR, 1.23; 95% CI, 1.08-1.41). Adding depressive symptoms in the model did not change this association (HR, 1.22; 95% CI, 1.07-1.40). Neither race and ethnicity nor age moderated the association between social isolation and incident HF. Conclusions Socially isolated older women are at increased risk for developing HF, independent of traditional HF risk factors. Registration URL: http://www.clinicaltrials.gov; Unique identifier: NCT00000611.
dc.language.isoen
dc.publisherWiley Blackwell
dc.rightsCopyright © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectheart failure
dc.subjectolder adults
dc.subjectsocial isolation
dc.subjectwomen
dc.titleSocial Isolation and Incident Heart Failure Hospitalization in Older Women: Women's Health Initiative Study Findings
dc.typeArticle
dc.typetext
dc.contributor.departmentUniversity of Arizona
dc.identifier.journalJournal of the American Heart Association
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleJournal of the American Heart Association
refterms.dateFOA2022-03-31T21:13:42Z


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Copyright © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.
Except where otherwise noted, this item's license is described as Copyright © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.