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dc.contributor.authorMorris, C.C.
dc.contributor.authorRef, J.
dc.contributor.authorAcharya, S.
dc.contributor.authorJohnson, K.J.
dc.contributor.authorSquire, S.
dc.contributor.authorAcharya, T.
dc.contributor.authorDennis, T.
dc.contributor.authorDaugherty, S.
dc.contributor.authorMcArthur, A.
dc.contributor.authorChinyere, I.R.
dc.contributor.authorKoevary, J.W.
dc.contributor.authorHare, J.M.
dc.contributor.authorLancaster, J.J.
dc.contributor.authorGoldman, S.
dc.contributor.authorAvery, R.
dc.date.accessioned2022-04-11T23:18:38Z
dc.date.available2022-04-11T23:18:38Z
dc.date.issued2022
dc.identifier.citationMorris, C. C., Ref, J., Acharya, S., Johnson, K. J., Squire, S., Acharya, T., Dennis, T., Daugherty, S., McArthur, A., Chinyere, I. R., Koevary, J. W., Hare, J. M., Lancaster, J. J., Goldman, S., & Avery, R. (2022). Free-breathing gradient recalled echo-based CMR in a swine heart failure model. Scientific Reports.
dc.identifier.issn2045-2322
dc.identifier.pmid35260607
dc.identifier.doi10.1038/s41598-022-07611-8
dc.identifier.urihttp://hdl.handle.net/10150/663992
dc.description.abstractIn swine models, there are well-established protocols for creating a closed-chest myocardial infarction (MI) as well as protocols for characterization of cardiac function with cardiac magnetic resonance (CMR). This methods manuscript outlines a novel technique in CMR data acquisition utilizing smart-signal gradient recalled echo (GRE)-based array sequences in a free-breathing swine heart failure model allowing for both high spatial and temporal resolution imaging. Nine male Yucatan mini swine weighing 48.7 ± 1.6 kg at 58.2 ± 3.1 weeks old underwent the outlined imaging protocol before and 1-month after undergoing closed chest left anterior descending coronary artery (LAD) occlusion/reperfusion. The left ventricular ejection fraction (LVEF) at baseline was 59.3 ± 2.4% and decreased to 48.1 ± 3.7% 1-month post MI (P = 0.029). The average end-diastolic volume (EDV) at baseline was 55.2 ± 1.7 ml and increased to 74.2 ± 4.2 ml at 1-month post MI (P = 0.001). The resulting images from this novel technique and post-imaging analysis are presented and discussed. In a Yucatan swine model of heart failure via closed chest left anterior descending coronary artery (LAD) occlusion/reperfusion, we found that CMR with GRE-based array sequences produced clinical-grade images with high spatial and temporal resolution in the free-breathing setting. © 2022, The Author(s).
dc.language.isoen
dc.publisherNature Research
dc.rightsCopyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleFree-breathing gradient recalled echo-based CMR in a swine heart failure model
dc.typeArticle
dc.typetext
dc.contributor.departmentCollege of Medicine, University of Arizona
dc.contributor.departmentDepartment of Chemistry and Biochemistry, University of Arizona
dc.contributor.departmentMagnetic Resonance Research Facility, University of Arizona
dc.contributor.departmentMagnetic Resonance Research Facility, University of Arizona
dc.contributor.departmentSarver Heart Center, University of Arizona
dc.contributor.departmentDepartment of Biomedical Engineering, University of Arizona
dc.identifier.journalScientific Reports
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleScientific Reports
refterms.dateFOA2022-04-11T23:18:38Z


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Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.