Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads
Author
Ramiro, I.B.L.Bjørn-Yoshimoto, W.E.
Imperial, J.S.
Gajewiak, J.
Florez Salcedo, P.
Watkins, M.
Taylor, D.
Resager, W.
Ueberheide, B.
Brauner-Osborne, H.
Whitby, F.G.
Hill, C.P.
Martin, L.F.
Patwardhan, A.
Concepcion, G.P.
Olivera, B.M.
Safavi-Hemami, H.
Affiliation
Department of Anesthesiology and Pharmacology, University of ArizonaIssue Date
2022
Metadata
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Ramiro, I. B. L., Bjørn-Yoshimoto, W. E., Imperial, J. S., Gajewiak, J., Florez Salcedo, P., Watkins, M., Taylor, D., Resager, W., Ueberheide, B., Brauner-Osborne, H., Whitby, F. G., Hill, C. P., Martin, L. F., Patwardhan, A., Concepcion, G. P., Olivera, B. M., & Safavi-Hemami, H. (2022). Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads. Science Advances.Journal
Science AdvancesRights
Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential. © 2022 American Association for the Advancement of Science. All rights reserved.Note
Open access journalISSN
2375-2548PubMed ID
35319982Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1126/sciadv.abk1410
Scopus Count
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Except where otherwise noted, this item's license is described as Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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