Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging
dc.contributor.author | Sonar, Sandip Ashok | |
dc.contributor.author | Uhrlaub, Jennifer L | |
dc.contributor.author | Coplen, Christopher P | |
dc.contributor.author | Sempowski, Gregory D | |
dc.contributor.author | Dudakov, Jarrod A | |
dc.contributor.author | van den Brink, Marcel R M | |
dc.contributor.author | LaFleur, Bonnie J | |
dc.contributor.author | Jergović, Mladen | |
dc.contributor.author | Nikolich-Žugich, Janko | |
dc.date.accessioned | 2022-05-17T19:30:27Z | |
dc.date.available | 2022-05-17T19:30:27Z | |
dc.date.issued | 2022-04-19 | |
dc.identifier.citation | Sonar, S. A., Uhrlaub, J. L., Coplen, C. P., Sempowski, G. D., Dudakov, J. A., van den Brink, M. R. M., LaFleur, B. J., Jergović, M., & Nikolich-Žugich, J. (2022). Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging. Proceedings of the National Academy of Sciences of the United States of America. | en_US |
dc.identifier.pmid | 35439062 | |
dc.identifier.doi | 10.1073/pnas.2121028119 | |
dc.identifier.uri | http://hdl.handle.net/10150/664224 | |
dc.description.abstract | Significance: Older adults are more vulnerable to infection and less capable of vigorously responding to vaccination. The contribution of peripheral T cell maintenance defects to these processes is incompletely understood. Here, we provide evidence that lymph nodes (LNs), which are critical for naive T (TN) cell maintenance and initiation of new immune responses, age asynchronously. Skin-draining LNs undergo early (6 to 9 mo) and deeper LN and spleen late-life (18 mo) atrophy, characterized by reduced ability to maintain TN cells, structural and numerical loss of LN stromal cell microenvironments, and reduced immunity to cutaneous vaccination. These results highlight the critical role of age-related LN atrophy in functional immunity and immune homeostasis. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PNAS | en_US |
dc.rights | Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative CommonsAttribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | aging | en_US |
dc.subject | homeostasis | en_US |
dc.subject | secondary lymphoid organs | en_US |
dc.subject | T cells | en_US |
dc.title | Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1091-6490 | |
dc.contributor.department | Department of Immunobiology, University of Arizona College of Medicine-Tucson | en_US |
dc.contributor.department | Arizona Center on Aging, University of Arizona College of Medicine-Tucson | en_US |
dc.contributor.department | BIO5 Institute, University of Arizona | en_US |
dc.identifier.journal | Proceedings of the National Academy of Sciences of the United States of America | en_US |
dc.description.note | Open access article | en_US |
dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | en_US |
dc.eprint.version | Final published version | en_US |
dc.source.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | |
dc.source.volume | 119 | |
dc.source.issue | 17 | |
dc.source.beginpage | e2121028119 | |
dc.source.endpage | ||
refterms.dateFOA | 2022-05-17T19:30:28Z | |
dc.source.country | United States |