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dc.contributor.authorSonar, Sandip Ashok
dc.contributor.authorUhrlaub, Jennifer L
dc.contributor.authorCoplen, Christopher P
dc.contributor.authorSempowski, Gregory D
dc.contributor.authorDudakov, Jarrod A
dc.contributor.authorvan den Brink, Marcel R M
dc.contributor.authorLaFleur, Bonnie J
dc.contributor.authorJergović, Mladen
dc.contributor.authorNikolich-Žugich, Janko
dc.date.accessioned2022-05-17T19:30:27Z
dc.date.available2022-05-17T19:30:27Z
dc.date.issued2022-04-19
dc.identifier.citationSonar, S. A., Uhrlaub, J. L., Coplen, C. P., Sempowski, G. D., Dudakov, J. A., van den Brink, M. R. M., LaFleur, B. J., Jergović, M., & Nikolich-Žugich, J. (2022). Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging. Proceedings of the National Academy of Sciences of the United States of America.en_US
dc.identifier.pmid35439062
dc.identifier.doi10.1073/pnas.2121028119
dc.identifier.urihttp://hdl.handle.net/10150/664224
dc.description.abstractSignificance: Older adults are more vulnerable to infection and less capable of vigorously responding to vaccination. The contribution of peripheral T cell maintenance defects to these processes is incompletely understood. Here, we provide evidence that lymph nodes (LNs), which are critical for naive T (TN) cell maintenance and initiation of new immune responses, age asynchronously. Skin-draining LNs undergo early (6 to 9 mo) and deeper LN and spleen late-life (18 mo) atrophy, characterized by reduced ability to maintain TN cells, structural and numerical loss of LN stromal cell microenvironments, and reduced immunity to cutaneous vaccination. These results highlight the critical role of age-related LN atrophy in functional immunity and immune homeostasis.en_US
dc.language.isoenen_US
dc.publisherPNASen_US
dc.rightsCopyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative CommonsAttribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectagingen_US
dc.subjecthomeostasisen_US
dc.subjectsecondary lymphoid organsen_US
dc.subjectT cellsen_US
dc.titleEarly age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with agingen_US
dc.typeArticleen_US
dc.identifier.eissn1091-6490
dc.contributor.departmentDepartment of Immunobiology, University of Arizona College of Medicine-Tucsonen_US
dc.contributor.departmentArizona Center on Aging, University of Arizona College of Medicine-Tucsonen_US
dc.contributor.departmentBIO5 Institute, University of Arizonaen_US
dc.identifier.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.description.noteOpen access articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleProceedings of the National Academy of Sciences of the United States of America
dc.source.volume119
dc.source.issue17
dc.source.beginpagee2121028119
dc.source.endpage
refterms.dateFOA2022-05-17T19:30:28Z
dc.source.countryUnited States


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Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative CommonsAttribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).
Except where otherwise noted, this item's license is described as Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative CommonsAttribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).