Anti-Aging Effects of Rapamycin; Resveratrol; and Topical Melatonin on the Skin

Abstract

Specific Aims: The specific aim of this study is to explore the effects of topical melatonin, resveratrol, and rapamycin on slowing the progression of and reversing skin aging symptoms.

Methods: A comprehensive search strategy using keywords for 'topical melatonin,' 'resveratrol,' 'rapamycin,' and 'skin aging' was developed. Articles were identified through a systematic search of bibliographic databases. Interventional and observational studies in humans or human skin cells were included if at least one group received one of the active ingredients of focus, and at least one outcome related to skin anti-aging was reported. Three investigators worked through disagreements on inclusion eligibility through discussion and consensus generation and bias assessment was performed.

Main Results: There were a total of 17 studies that met inclusion criteria. Overall, the studies involving topical melatonin and resveratrol, positive outcomes included skin wrinkle reduction, increased skin hydration, improved skin tonicity or complexion, and reduction in hyperpigmentation, or age spots. Outcomes of the one article on rapamycin that met inclusion criteria included an increase in dermal thickness, diameter, and density of collagen fibers.

Conclusions: Available studies identified through this systematic review suggest that resveratrol and topical melatonin appear to be modestly effective at reducing the appearance of aged skin. While a body of literature exists that examines rapamycin on a molecular level, more human studies must be carried out in order to gain a better understanding of its potential benefits on skin aging.