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dc.contributor.authorMerker, J.B.
dc.contributor.authorDixon, H.D.
dc.contributor.authorGluck, R.
dc.contributor.authorKim, Y.J.
dc.contributor.authorPowers, A.
dc.contributor.authorSchwartz, A.C.
dc.contributor.authorJovanovic, T.
dc.contributor.authorUmpierrez, G.
dc.contributor.authorRessler, K.J.
dc.contributor.authorMichopoulos, V.
dc.contributor.authorPace, T.W.W.
dc.contributor.authorGillespie, C.F.
dc.contributor.authorSeligowski, A.V.
dc.date.accessioned2022-08-01T20:21:25Z
dc.date.available2022-08-01T20:21:25Z
dc.date.issued2022
dc.identifier.citationMerker, J. B., Dixon, H. D., Gluck, R., Kim, Y. J., Powers, A., Schwartz, A. C., Jovanovic, T., Umpierrez, G., Ressler, K. J., Michopoulos, V., Pace, T. W. W., Gillespie, C. F., & Seligowski, A. V. (2022). Heart rate variability and HbA1c predict plasma interleukin-6 response to psychosocial stress challenge in trauma-exposed women with type 2 diabetes. Brain, Behavior, and Immunity - Health, 19.
dc.identifier.issn2666-3546
dc.identifier.doi10.1016/j.bbih.2021.100400
dc.identifier.urihttp://hdl.handle.net/10150/665523
dc.description.abstractBackground: Type 2 diabetes mellitus (T2DM) is a major public health problem in the United States. Although cardiovascular autonomic functioning, blood glucose control, and inflammation are known to play a role in T2DM, the interaction between these variables remains largely unexplored, particularly in the context of stress. To address this gap, we examined the relationship between these variables in a sample that is uniquely vulnerable to the health consequences of T2DM. Methods: Participants were 37 trauma-exposed Black women with a diagnosis of T2DM. High frequency heart rate variability (HF-HRV), blood glucose control (HbA1c), and a stressor-evoked biomarker of inflammation (interleukin 6; IL-6) were obtained as part of a larger study of the genetic risk factors for and consequences of trauma exposure. Results: The interaction of HbA1c and HF-HRV was significantly associated with IL-6 response calculated as area under the curve with respect to ground. Post-hoc simple slopes analyses revealed HbA1c, rather than HF-HRV, as the moderator in this association such that higher HF-HRV conferred higher circulating levels of IL-6 only in the presence of lower HbA1c, (β ​= ​0.60, t ​= ​3.51, p ​= ​.001). Conclusions: Cardiovascular autonomic functioning and blood glucose control were significantly associated with stressor-evoked IL-6 responses when controlling for BMI and age. Moreover, the association between cardiovascular autonomic functioning and inflammation varied at different levels of HbA1c. This highlights the possibility that individuals with trauma exposure and T2DM may benefit from stratification by HbA1c levels for research analysis and treatment decision making. © 2021 The Authors
dc.language.isoen
dc.publisherElsevier Inc.
dc.rightsCopyright © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.subjectBlood glucose control
dc.subjectHeart rate variability
dc.subjectInflammation
dc.subjectTrauma
dc.subjectType II diabetes mellitus
dc.titleHeart rate variability and HbA1c predict plasma interleukin-6 response to psychosocial stress challenge in trauma-exposed women with type 2 diabetes
dc.typeArticle
dc.typetext
dc.contributor.departmentCollege of Nursing and College of Medicine (Psychiatry), University of Arizona
dc.identifier.journalBrain, Behavior, and Immunity - Health
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleBrain, Behavior, and Immunity - Health
refterms.dateFOA2022-08-01T20:21:25Z


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Copyright © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Except where otherwise noted, this item's license is described as Copyright © 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).