Antimicrobial activity of some celastroloids and their derivatives
AuthorInácio, Marielle Cascaes
Paz, Tiago Antunes
Wijeratne, E. M. Kithsiri
Gunaherath, G. M. Kamal B.
Guido, Rafael V. C.
Gunatilaka, A. A. Leslie
AffiliationSouthwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona
MetadataShow full item record
PublisherSpringer Science and Business Media LLC
CitationInácio, M. C., Paz, T. A., Wijeratne, E. M. K., Gunaherath, G. M. K. B., Guido, R. V. C., & Gunatilaka, A. A. L. (2022). Antimicrobial activity of some celastroloids and their derivatives. Medicinal Chemistry Research.
JournalMedicinal Chemistry Research
Rights© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractInfections are among the 10 deadliest diseases in the world. Here we screened 19 celastroloids and their derivatives 1–19 against several strains of bacteria and yeast of biomedical significance. In general, quinonemethide-type celastroloids, except isoiguesterin (8) exhibited significant antibacterial activity for Staphylococcus aureus ATCC 25923, MRSA ATCC 33592, and the clinical isolate STA6 with MICs of 0.39–12.50 µg/mL, whereas 14(15)-enequinonemethide, balaenol (12), showed antifungal activity against Candida albicans ATCC 10261 with an MIC of 3.12 µg/mL. Among the phenolic triterpenes and their derivatives, zeylasterone (14) had an MIC of 1.56 µg/mL for all 3 strains of S. aureus, and zeylasteral (15) was active against C. albicans at 3.12 µg/mL. Cytotoxicity assays revealed that most quinonemethides were cytotoxic with IC50s of 0.16–0.36 µg/mL that are below their MIC values. However, 14(15)-enequinonemethide 12 and phenolic triterpenes 14 and 15 exhibited antimicrobial activity at sub-cytotoxic concentrations, suggesting that these celastroloids are potential candidates for further studies. Molecular docking studies were used to investigate the theoretical affinities for potential protein targets of 12 and 14 in S. aureus, and 15 in C. albicans. Based on their docking scores, it can be inferred that 12 and 14 inhibits GyrB in S. aureus, and 15 inhibits Bdf1 in C. albicans.
Note12 month embargo; published: 13 July 2022
VersionFinal accepted manuscript