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dc.contributor.authorDeshpande, Aditi
dc.contributor.authorElliott, Jordan
dc.contributor.authorKari, Nitya
dc.contributor.authorJiang, Bin
dc.contributor.authorMichel, Patrik
dc.contributor.authorToosizadeh, Nima
dc.contributor.authorFahadan, Pouya Tahsili
dc.contributor.authorKidwell, Chelsea
dc.contributor.authorWintermark, Max
dc.contributor.authorLaksari, Kaveh
dc.date.accessioned2022-08-05T18:49:01Z
dc.date.available2022-08-05T18:49:01Z
dc.date.issued2022-07-15
dc.identifier.citationDeshpande, A., Elliott, J., Kari, N., Jiang, B., Michel, P., Toosizadeh, N., Fahadan, P. T., Kidwell, C., Wintermark, M., & Laksari, K. (2022). Novel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer’s disease. Journal of Neuroimaging.en_US
dc.identifier.issn1051-2284
dc.identifier.doi10.1111/jon.13023
dc.identifier.urihttp://hdl.handle.net/10150/665554
dc.description.abstractBackground and Purpose: Altered brain vasculature is a key phenomenon in several neurologic disorders. This paper presents a quantitative assessment of the anatomical variations in the Circle of Willis (CoW) and vascular morphology in healthy aging, acute ischemic stroke (AIS) and Alzheimer's Disease (AD). Methods: We used our novel automatic method to segment and extract geometric features of the cerebral vasculature from MR angiography scans of 175 healthy subjects, which were used to create a probabilistic atlas of cerebrovasculature and to study normal aging and intersubject variations in CoW anatomy. Subsequently, we quantified and analyzed vascular alterations in 45AIS and 50 AD patients, two prominent cerebrovascular and neurodegenerative disorders. Results: In the sampled cohort, we determined that the CoW is fully formed in only 35% of healthy adults and found significantly (p <.05) increased tortuosity and fractality, with increasing age and also with disease in both AIS and AD. We also found significantly lower vessel length, volume, and number of branches in AIS patients, as expected. The AD cerebral vessels exhibited significantly smaller diameter and more complex branching patterns, compared to age-matched healthy adults. These changes were significantly heightened (p <.05) among healthy, early onset mild AD, and moderate/severe dementia groups. Conclusion: Although our study does not include longitudinal data due to paucity of such datasets, the specific geometric features and quantitative comparisons demonstrate the potential for using vascular morphology as a noninvasive imaging biomarker for neurologic disorders.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rights© 2022 American Society of Neuroimaging.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectagingen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectcerebral vasculatureen_US
dc.subjectimagingen_US
dc.subjectstrokeen_US
dc.titleNovel imaging markers for altered cerebrovascular morphology in aging, stroke, and Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.eissn1552-6569
dc.contributor.departmentDepartment of Biomedical Engineering, University of Arizonaen_US
dc.contributor.departmentDepartment of Aerospace and Mechanical Engineering, University of Arizonaen_US
dc.identifier.journalJournal of Neuroimagingen_US
dc.description.note12 month embargo; first published: 15 July 2022en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.identifier.pii10.1111/jon.13023
dc.source.journaltitleJournal of Neuroimaging


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