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dc.contributor.authorKlimentidis, Yann C
dc.contributor.authorNewell, Michelle
dc.contributor.authorVan Der Zee, Matthijs D.
dc.contributor.authorBland, Victoria L.
dc.contributor.authorMay-Wilson, Sebastian
dc.contributor.authorArani, Gayatri
dc.contributor.authorMenni, Cristina
dc.contributor.authorMangino, Massimo
dc.contributor.authorArora, Amit
dc.contributor.authorRaichlen, David A.
dc.contributor.authorAlexander, Gene E.
dc.contributor.authorWilson, James F.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorDe Geus, Eco J.C.
dc.contributor.authorPirastu, Nicola
dc.date.accessioned2022-08-08T22:45:53Z
dc.date.available2022-08-08T22:45:53Z
dc.date.issued2022-03-11
dc.identifier.citationKlimentidis, Y. C., Newell, M., Van Der Zee, M. D., Bland, V. L., May-Wilson, S., Arani, G., Menni, C., Mangino, M., Arora, A., Raichlen, D. A., Alexander, G. E., Wilson, J. F., Boomsma, D. I., Hottenga, J.-J., De Geus, E. C. O. J. C., & Pirastu, N. (2022). Genome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohorts. Medicine and Science in Sports and Exercise, 54(8), 1252–1260.en_US
dc.identifier.pmid35320144
dc.identifier.doi10.1249/MSS.0000000000002907
dc.identifier.urihttp://hdl.handle.net/10150/665564
dc.description.abstractIntroduction A lack of physical activity (PA) is one of the most pressing health issues today. Our individual propensity for PA is influenced by genetic factors. Stated liking of different PA types may help capture additional and informative dimensions of PA behavior genetics. Methods In over 157,000 individuals from the UK Biobank, we performed genome-wide association studies of five items assessing the liking of different PA types, plus an additional derived trait of overall PA-liking. We attempted to replicate significant associations in the Netherlands Twin Register (NTR) and TwinsUK. Additionally, polygenic scores (PGS) were trained in the UK Biobank for each PA-liking item and for self-reported PA behavior, and tested for association with PA in the NTR. Results We identified a total of 19 unique significant loci across all five PA-liking items and the overall PA-liking trait, and these showed strong directional consistency in the replication cohorts. Four of these loci were previously identified for PA behavior, including CADM2, which was associated with three PA-liking items. The PA-liking items were genetically correlated with self-reported (rg = 0.38-0.80) and accelerometer (rg = 0.26-0.49) PA measures, and with a wide range of health-related traits. Each PA-liking PGS significantly predicted the same PA-liking item in NTR. The PGS of liking for going to the gym predicted PA behavior in the NTR (r2 = 0.40%) nearly as well as a PGS based on self-reported PA behavior (r2 = 0.42%). Combining the two PGS into a single model increased the r2 to 0.59%, suggesting that PA-liking captures distinct and relevant dimensions of PA behavior. Conclusions We have identified the first loci associated with PA-liking and extended our understanding of the genetic basis of PA behavior.en_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.rightsCopyright © 2022 by the American College of Sports Medicine.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectExerciseen_US
dc.subjectGeneticen_US
dc.subjectGenome-wide association studyen_US
dc.subjectLikingen_US
dc.subjectPhysical activityen_US
dc.subjectPreferencesen_US
dc.titleGenome-wide Association Study of Liking for Several Types of Physical Activity in the UK Biobank and Two Replication Cohortsen_US
dc.typeArticleen_US
dc.identifier.eissn1530-0315
dc.contributor.departmentDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizonaen_US
dc.contributor.departmentDepartment of Psychology and Psychiatry, University of Arizonaen_US
dc.contributor.departmentEvelyn F. McKnight Brain Institute, University of Arizonaen_US
dc.contributor.departmentNeuroscience and Physiological Sciences Graduate Inter-Disciplinary Programs, University of Arizonaen_US
dc.identifier.journalMedicine and science in sports and exerciseen_US
dc.description.note12 month embargo; published 01 August 2022en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleMedicine and science in sports and exercise
dc.source.volume54
dc.source.issue8
dc.source.beginpage1252
dc.source.endpage1260
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryUnited States


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