Metabolic Benefits of Improving Cardiac Function
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Embargo
Thesis not available (per author's request)Abstract
Type 2 diabetes mellitus (T2DM) affects 422 million people worldwide. Cardiovascular disease is the leading cause of death in people with type 2 diabetes. In this review, we aim to understand the potential metabolic benefits of improving microvascular blood flow. We discuss the positive relationship between tissue vascular perfusion and insulin sensitivity, highlight the hormonal regulators of blood flow, and look at physiological states that affect blood flow including obesity, fasting/feeding, heat exposure and exercise. Finally, we cover the effects of vasodilators on glucose metabolism and discuss the potential to develop blood flow focused novel drug therapeutics for T2DMType
textElectronic Thesis
Degree Name
M.S.Degree Level
mastersDegree Program
Graduate CollegeAnimal Sciences