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dc.contributor.authorPeila, R.
dc.contributor.authorXue, X.
dc.contributor.authorFeliciano, E.M.C.
dc.contributor.authorAllison, M.
dc.contributor.authorSturgeon, S.
dc.contributor.authorZaslavsky, O.
dc.contributor.authorStone, K.L.
dc.contributor.authorOchs-Balcom, H.M.
dc.contributor.authorMossavar-Rahmani, Y.
dc.contributor.authorCrane, T.E.
dc.contributor.authorAggarwal, M.
dc.contributor.authorWassertheil-Smoller, S.
dc.contributor.authorRohan, T.E.
dc.date.accessioned2022-10-24T23:49:44Z
dc.date.available2022-10-24T23:49:44Z
dc.date.issued2022
dc.identifier.citationPeila, R., Xue, X., Feliciano, E. M. C., Allison, M., Sturgeon, S., Zaslavsky, O., Stone, K. L., Ochs-Balcom, H. M., Mossavar-Rahmani, Y., Crane, T. E., Aggarwal, M., Wassertheil-Smoller, S., & Rohan, T. E. (2022). Association of sleep duration and insomnia with metabolic syndrome and its components in the Women’s Health Initiative. BMC Endocrine Disorders, 22(1), 228.
dc.identifier.issn1472-6823
dc.identifier.pmid36104689
dc.identifier.doi10.1186/s12902-022-01138-9
dc.identifier.urihttp://hdl.handle.net/10150/666458
dc.description.abstractBACKGROUND: Epidemiological evidence suggests that inadequate sleep duration and insomnia may be associated with increased risk of metabolic syndrome (MetS). However, longitudinal data with repeated measures of sleep duration and insomnia and of MetS are limited. We examined the association of sleep duration and insomnia with MetS and its components using longitudinal data from the Women's Health Initiative (WHI). METHODS: The study included postmenopausal women (ages 50-79 years) diabetes-free at enrollment in the WHI, with baseline data on sleep duration (n = 5,159), insomnia (n = 5,063), MetS, and its components. Repeated measures of self-reported sleep duration and insomnia were available from years 1 or 3 of follow-up and of the MetS components from years 3, 6 and 9. Associations were assessed using logistic regression and generalized estimating equations models, and odds ratios and 95% confidence intervals (CI) adjusted for major risk factors were calculated. RESULTS: In cross-sectional analysis, baseline sleep duration ≥ 9 h was positively associated with MetS (OR = 1.51; 95%CI 1.12-2.04), while sleep duration of 8- < 9 h was associated with waist circumference > 88 cm and triglycerides ≥ 150 mg/dL (OR = 1.18; 95%CI 1.01-1.40 and OR = 1.23; 95%CI 1.05-1.46, respectively). Insomnia had a borderline positive association with MetS (OR = 1.14; 95%CI 0.99-1.31), and significant positive associations with waist circumference > 88 cm and glucose ≥ 100 mg/dL (OR = 1.18; 95%CI 1.03-1.34 and OR = 1.17; 95%CI 1.02-1.35, respectively). In the longitudinal analysis, change from restful sleep to insomnia over time was associated with increased odds of developing MetS (OR = 1.40; 95%CI 1.01-1.94), and of a triglyceride level ≥ 150 mg/dL (OR = 1.48; 95%CI 1.08-2.03). CONCLUSIONS: Among postmenopausal women in the WHI, sleep duration and insomnia were associated with current and future risk of MetS and some of its components. © 2022. The Author(s).
dc.language.isoen
dc.publisherBMC
dc.rightsCopyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectInsomnia
dc.subjectLongitudinal study
dc.subjectMetabolic syndrome
dc.subjectPostmenopausal women
dc.subjectSleep duration
dc.titleAssociation of sleep duration and insomnia with metabolic syndrome and its components in the Women's Health Initiative
dc.typeArticle
dc.typetext
dc.contributor.departmentBehavioral Measurement and Interventions Cancer Prevention and Control Program, University of Arizona
dc.identifier.journalBMC Endocrine Disorders
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleBMC endocrine disorders
refterms.dateFOA2022-10-24T23:49:44Z


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Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.