• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Honors Theses
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Honors Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    MENOPAUSAL IMPLICATIONS ON CARDIOVASCULAR DISEASE CAN BE MITIGATED BY PREBIOTIC TREATMENT

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_hr_2021_0132_sip1_m.pdf
    Size:
    5.963Mb
    Format:
    PDF
    Download
    Author
    LEBER, CHRISTIAN JOHN
    Issue Date
    2021
    Advisor
    Konhilas, John
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Cardiovascular disease has continued to be the leading cause of death globally, and females are prone to an increased risk due to the transition to menopause. Menopause effects female physiology systemically and in this study, we aimed to better understand the changes associated with menopause in the gut microbiome and the difference in cardiac protection following the onset of menopause. Additionally, we analyzed the effects of a prebiotic, Oligofructose (OFS), on female mice as they transitioned to menopause, in effort to mitigate the negative effects associated with menopause. Using proteomic analysis and immunohistochemical staining of gut tissue from four mice groups we found that menopause changes the gut microbiome and diminishes certain bacterial colonies involved in suppressing inflammation. Moreover, we found that OFS helps mitigate this change and promotes the growth of other bacterial colonies that suppress inflammation locally and systemically. Through immunohistochemical staining of the murine cardiac tissue after undergoing a controlled myocardial infarction (MI) and subsequent ischemic reperfusion we found similar results. Menopausal mice had increased ischemic damage following 3-day MI compared to premenopausal mice. Additionally, OFS treatment was shown to mitigate this increased damage likely due to suppressing inflammatory pathways in the heart. Overall, we elucidated that menopause increases infarct size and that in the presence of OFS infarct size is comparable to premenopausal models and heart inflammation is decreased.
    Type
    Electronic thesis
    text
    Degree Name
    B.S.H.S.
    Degree Level
    bachelors
    Degree Program
    Physiology
    Honors College
    Degree Grantor
    University of Arizona
    Collections
    Honors Theses

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.