Visceral adipose tissue and cardiometabolic risk factors in young Hispanic and non-Hispanic girls
Affiliation
School of Nutritional Sciences and Wellness, University of ArizonaUniversity of Arizona Cancer Center
Department of Epidemiology and Biostatistics, University of Arizona
Issue Date
2022
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Frontiers Media S.A.Citation
Bland, V. L., Kindler, J. M., Blew, R. M., Morrill, K. E., Roe, D. J., & Going, S. B. (2022). Visceral adipose tissue and cardiometabolic risk factors in young Hispanic and non-Hispanic girls. Frontiers in Pediatrics, 10.Journal
Frontiers in PediatricsRights
Copyright © 2022 Bland, Kindler, Blew, Morrill, Roe and Going. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background: Risk factors for cardiometabolic diseases (e.g., type 2 diabetes, cardiovascular disease) can begin developing in childhood. Elevated body mass index (BMI) is associated with greater likelihood of developing such diseases; however, this relationship varies by race and ethnicity. Notably, Hispanics tend to have high rates of obesity and are disproportionately affected by type 2 diabetes. We aimed to determine if visceral adiposes tissue (VAT) is associated with cardiometabolic risk factors (i.e., triglycerides, cholesterol, insulin resistance, C-reactive protein, and blood pressure), independent of BMI percentile, in a sample of primarily Hispanic adolescent girls. Methods and results: A total of 337 girls (73% Hispanic) took part in the cross-sectional study. Hispanic girls generally had greater BMI percentile, VAT, and cardiometabolic risk factors compared to non-Hispanic girls. Multiple linear regression was used to assess the relationships between Dual-energy X-ray Absorptiometry (DXA)-derived VAT and cardiometabolic outcomes, controlling for BMI percentile (<85th percentile or ≥85th percentile), age, ethnicity (Hispanic/non-Hispanic), and Tanner stage. Significant interactions between VAT and BMI percentile were identified for almost all cardiometabolic outcomes. Upon stratification, the association between VAT and cardiometabolic outcomes was strongest in girls ≥85th BMI percentile, as compared to girls <85th percentile. However, VAT was only significantly associated with higher triglycerides (girls ≥85th percentile) and higher insulin resistance (both BMI percentiles) after stratification. Conclusion: VAT was associated with increased triglycerides and insulin resistance in girls with overweight or obesity. These findings warrant further investigation between VAT and cardiometabolic health in Hispanic adolescents who tend to accumulate more adipose tissue during adolescence. Copyright © 2022 Bland, Kindler, Blew, Morrill, Roe and Going.Note
Open access journalISSN
2296-2360Version
Final published versionae974a485f413a2113503eed53cd6c53
10.3389/fped.2022.892206
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Except where otherwise noted, this item's license is described as Copyright © 2022 Bland, Kindler, Blew, Morrill, Roe and Going. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).