Show simple item record

dc.contributor.authorMcGraw, M.B.
dc.contributor.authorKohler, L.N.
dc.contributor.authorShaibi, G.Q.
dc.contributor.authorMandarino, L.J.
dc.contributor.authorColetta, D.K.
dc.date.accessioned2022-12-15T22:41:41Z
dc.date.available2022-12-15T22:41:41Z
dc.date.issued2022
dc.identifier.citationMcGraw, M. B., Kohler, L. N., Shaibi, G. Q., Mandarino, L. J., & Coletta, D. K. (2022). A performance review of novel adiposity indices for assessing insulin resistance in a pediatric Latino population. Frontiers in Pediatrics, 10.
dc.identifier.issn2296-2360
dc.identifier.doi10.3389/fped.2022.1020901
dc.identifier.urihttp://hdl.handle.net/10150/667241
dc.description.abstractIntroduction: Body mass index (BMI) percentile or BMI adjusted for age and sex is the most common anthropometric index to monitor and assess obesity in children. However, the ability of BMI to accurately predict insulin resistance (IR) in youth is debated. Determining the best method to noninvasively measure IR in the pediatric population is especially important due to the growing prevalence of type 2 diabetes mellitus (T2DM), which is more likely to develop in people with IR. Therefore, this study analyzed the performance of BMI against newer anthropometric indices in assessing IR in a pediatric Latino identifying sample. Methods: We studied 127 pediatric Latino participants from the Arizona Insulin Resistance (AIR) registry and performed linear regression analyses between various measures of IR and adiposity indices, including body mass index (BMI), triponderal mass index (TMI), body adiposity index (BAI), pediatric body adiposity index (pBAI), a body shape index (ABSI), abdominal volume index (AVI), waist to height ratio (WtHR) and waist to hip ratio (WHR). Log transformations of each index adjusted for age and sex and IR were used for the linear regressions. Additionally, we generated receiver operating characteristics (ROC) from logistic regressions between HOMA-IR and HOMA2IR against the same indices. Results: Using the homeostatic assessment of insulin resistance (HOMA-IR), HOMA2IR, the quantitative insulin-sensitivity check index (QUICKI), fasting serum insulin, and FPG/FSI to measure IR, we showed that BMI adjusted for age and sex performs similarly to many of the newer indices in our sample. The correlation coefficients for pBAI [R2: 0.27, 95% confidence interval: 0.88–1.81, p < 0.001] and BMI [R2: 0.27, 95% confidence interval: 0.92–1.92, p < 0.001] were the highest for HOMA-IR. Similarly, pBAI [R2: 0.29, 95% confidence interval: 0.88–1.72, p < 0.001] and BMI [R2: 0.29, 95% confidence interval: 0.93–1.83, p < 0.001] were the highest for HOMA2IR. A similar trend was observed with QUICKI, FSI, and FPG/FSI. ABSI had the lowest R2 value for all measures of IR. Area under the curve (AUC) values for the receiver operating characteristics (ROC) for HOMA-IR and HOMA2IR support these conclusions. Conclusions: BMI adjusted for age and sex, despite its usage and simplicity, still stacks up well against newer indices in our Latino sample. Testing these indices across larger samples is necessary to generalize these findings and translate performance to adults. 2022 McGraw, Kohler, Shaibi, Mandarino and Coletta.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rightsCopyright © 2022 McGraw, Kohler, Shaibi, Mandarino and Coletta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectadiposity indices
dc.subjectinsulin resistance
dc.subjectlatino (Hispanic)
dc.subjectobesity
dc.subjectpediatrics
dc.subjecttype 2 diabetes
dc.titleA performance review of novel adiposity indices for assessing insulin resistance in a pediatric Latino population
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Physiology, University of Arizona College of Medicine
dc.contributor.departmentCenter for Disparities in Diabetes, Obesity and Metabolism, University of Arizona
dc.contributor.departmentDepartment of Medicine, Division of Endocrinology, University of Arizona College of Medicine
dc.identifier.journalFrontiers in Pediatrics
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleFrontiers in Pediatrics
refterms.dateFOA2022-12-15T22:41:41Z


Files in this item

Thumbnail
Name:
fped-10-1020901.pdf
Size:
1.445Mb
Format:
PDF
Description:
Final Published Version

This item appears in the following Collection(s)

Show simple item record

Copyright © 2022 McGraw, Kohler, Shaibi, Mandarino and Coletta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Except where otherwise noted, this item's license is described as Copyright © 2022 McGraw, Kohler, Shaibi, Mandarino and Coletta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).