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dc.contributor.authorTan, Malinda S.
dc.contributor.authorHeise, C. William
dc.contributor.authorGallo, Tyler
dc.contributor.authorTisdale, James E.
dc.contributor.authorWoosley, Raymond L.
dc.contributor.authorAntonescu, Corneliu C.
dc.contributor.authorGephart, Sheila M.
dc.contributor.authorMalone, Daniel C.
dc.date.accessioned2023-01-06T01:43:30Z
dc.date.available2023-01-06T01:43:30Z
dc.date.issued2023-03
dc.identifier.citationTan, M. S., Heise, C. W., Gallo, T., Tisdale, J. E., Woosley, R. L., Antonescu, C. C., Gephart, S. M., & Malone, D. C. (2023). Relationship between a risk score for QT interval prolongation and mortality across rural and urban inpatient facilities. Journal of Electrocardiology, 77, 4–9.en_US
dc.identifier.issn0022-0736
dc.identifier.doi10.1016/j.jelectrocard.2022.11.008
dc.identifier.urihttp://hdl.handle.net/10150/667333
dc.description.abstractObjectives: To evaluate the relationship between a modified Tisdale QTc-risk score (QTc-RS) and inpatient mortality and length of stay in a broad inpatient population with an order for a medication with a known risk of torsades de pointes (TdP). Background: Managing the risk of TdP is challenging due to the number of medications with known risk of TdP and the complexity of precipitating factors. A model to predict risk of mortality may be useful to guide treatment decisions. Methods: This was a retrospective observational study using inpatient data from 28 healthcare facilities in the western United States. This risk score ranges from zero to 23 with weights applied to each risk factor based on a previous validation study. Logistic regression and a generalized linear model were performed to assess the relationship between QTc-RS and mortality and length of stay. Results: Between April and December 2020, a QTc-RS was calculated for 92,383 hospitalized patients. Common risk factors were female (55.0%); age > 67 years (32.1%); and receiving a medication with known risk of TdP (24.5%). A total of 2770 (3%) patients died during their hospitalization. Relative to patients with QTc-RS < 7, the odds ratio for mortality was 4.80 (95%CI:4.42–5.21) for patients with QTc-RS = 7–10 and 11.51 (95%CI:10.23–12.94) for those with QTc-RS ≥ 11. Length of hospital stay increased by 0.7 day for every unit increase in the risk score (p < 0.0001). Conclusion: There is a strong relationship between increased mortality as well as longer duration of hospitalization with an increasing QTc-RS.en_US
dc.description.sponsorshipU.S. Food and Drug Administrationen_US
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.rights© 2022 Elsevier Inc. All rights reserved.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectArrhythmiasen_US
dc.subjectCardiacen_US
dc.subjectMortalityen_US
dc.subjectTorsades de pointesen_US
dc.titleRelationship between a risk score for QT interval prolongation and mortality across rural and urban inpatient facilitiesen_US
dc.typeArticleen_US
dc.contributor.departmentDivision of Clinical Data Analytics and Decision Support, University of Arizona College of Medicine – Phoenixen_US
dc.contributor.departmentDepartment of Pharmacy Practice and Science, University of Arizona College of Pharmacyen_US
dc.contributor.departmentCommunity and Health Systems Science Division, College of Nursing, University of Arizonaen_US
dc.identifier.journalJournal of Electrocardiologyen_US
dc.description.note12 month embargo; available online: 09 December 2022en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.identifier.piiS0022073622002382
dc.source.journaltitleJournal of Electrocardiology
dc.source.volume77
dc.source.beginpage4
dc.source.endpage9


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