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Intraindividual Variability in Sleep and Levels of Systemic Inflammation in Nurses
Author
Slavish, Danica CTaylor, Daniel J
Dietch, Jessica R
Wardle-Pinkston, Sophie
Messman, Brett
Ruggero, Camilo J
Kohut, Marian
Kelly, Kimberly
Affiliation
Department of Psychology, University of ArizonaIssue Date
2020Keywords
sleepnurses
actigraphy
sleep diary
inflammation
intraindividual variability
BMI
body mass index
CRP
C-reactive protein
IL-1β
interleukin-1β
IL-6
interleukin-6
iM
intraindividual mean
IIV
intraindividual variability
LLD
lower limit of detection
sr2
semipartial correlations squared
TNF-α
tumor necrosis factor α
Metadata
Show full item recordPublisher
Lippincott Williams and WilkinsCitation
Slavish, D. C., Taylor, D. J., Dietch, J. R., Wardle-Pinkston, S., Messman, B., Ruggero, C. J., ... & Kelly, K. (2020). Intraindividual variability in sleep and levels of systemic inflammation in nurses. Psychosomatic medicine, 82(7), 678.Journal
Psychosomatic medicineRights
Copyright © 2020 by the American Psychosomatic Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Objective: Disturbed sleep is common among nurses and is associated with morbidity and mortality. Inflammation may be one mechanism linking sleep and disease. Yet most studies have relied on retrospective questionnaires to assess sleep, which fail to account for night-to-night fluctuations in sleep across time (i.e., intraindividual variability (IIV]). We examined prospective associations between mean and IIV in sleep with inflammation markers in nurses. Methods: Participants were 392 nurses (Mage = 39.54, 92% female; 23% night-shift working) who completed 7 days of sleep diaries and actigraphy to assess mean and IIV in total sleep time (TST) and sleep efficiency (SE). Blood was drawn on day 7 to assess inflammation markers C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β). Results: Greater intraindividual variability in TST — measured via both actigraphy and sleep diary — was associated with higher IL-6 (actigraphy β = 0.05, p = .046, sr2 = .01; diary β = 0.04, p = .030, sr2 = .01) and IL-1β (actigraphy β = 0.12, p = .008, sr2 = .02; diary β = 0.09, p = .025, sr2 = .01), but not CRP or TNF-α. IIV in actigraphy- and sleep diary-determined SE was not associated with inflammation biomarkers, nor were any mean sleep variables. Shift work did not moderate any associations. Conclusions: Nurses with more variable sleep durations had elevated levels of inflammation, which may increase risk for development of inflammatory-related diseases. Research should investigate how sleep regularization may change levels of inflammation and improve health.Note
12 month embargo; published 16 July 2020EISSN
1534-7796PubMed ID
32697443Version
Final accepted manuscriptae974a485f413a2113503eed53cd6c53
10.1097/PSY.0000000000000843