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dc.contributor.authorZhang, J.
dc.contributor.authorXiao, Y.
dc.contributor.authorLi, Z.-M.
dc.contributor.authorWei, N.
dc.contributor.authorLin, L.
dc.contributor.authorLi, K.
dc.date.accessioned2023-01-13T20:06:45Z
dc.date.available2023-01-13T20:06:45Z
dc.date.issued2022
dc.identifier.citationZhang, J., Xiao, Y., Li, Z.-M., Wei, N., Lin, L., & Li, K. (2022). Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease. Journal of NeuroEngineering and Rehabilitation, 19(1).
dc.identifier.issn1743-0003
dc.identifier.pmid36357939
dc.identifier.doi10.1186/s12984-022-01108-1
dc.identifier.urihttp://hdl.handle.net/10150/667541
dc.description.abstractThis study aimed to investigate the effects of early-stage Alzheimer’s disease (AD) on the reach-to-grasp kinematics and kinetics with and without visual supervision of the grasping arm and hand. Seventeen patients who had been diagnosed with early-stage AD and 17 age- and gender-matched, cognitive normal (CN) adults participated in the experiment. A mirror operating system was designed to block the visual feedback of their grasping hand and forearms but to virtually show grasped targets. The target for reach-to-grasp kinematics was a reflective marker installed on a base; and the target for reach-to-grasp kinetics was a custom-made apparatus installed with two six-component force/torque transducers. Kinematics and kinetic parameters were used to quantify the reach-to-grasp performances. Results showed that the early-stage AD remarkably decreased the reaching speed, reduced the grasping accuracy and increased the transportation variability for reach-to-grasp kinematics. For kinetic analysis, early-stage AD extended the preload duration, disturbed the grip and lift forces coordination, and increased the feedforward proportion in the grasping force control. The AD-related changes in the reach-to-grasp kinematic and kinetic parameters depended on visual feedback and were associated with nervous system function according to correlation analyses with the neuropsychological testing. These results suggest that the abnormal kinematic and kinetic characteristics may correlate with the neuropsychological status of early-stage AD, and that the reach-to-grasp kinematic and kinetic maneuver could potentially be used as a novel tool for non-invasive screening or evaluation of early-stage AD. © 2022, The Author(s).
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.rightsCopyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAlzheimer’s disease
dc.subjectKinematics
dc.subjectKinetics
dc.subjectReach-to-grasp performance
dc.subjectSensorimotor control
dc.titleReach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Orthopaedic Surgery, University of Arizona
dc.identifier.journalJournal of NeuroEngineering and Rehabilitation
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal published version
dc.source.journaltitleJournal of NeuroEngineering and Rehabilitation
refterms.dateFOA2023-01-13T20:06:45Z


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Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as Copyright © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License.