• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Geroscience submission-final_c ...
    Size:
    1.739Mb
    Format:
    PDF
    Description:
    Final Accepted Manuscript
    Download
    Author
    Jergović, Mladen
    Watanabe, Makiko
    Bhat, Ruchika
    Coplen, Christopher P
    Sonar, Sandip A
    Wong, Rachel
    Castaneda, Yvonne
    Davidson, Lisa
    Kala, Mrinalini
    Wilson, Rachel C
    Twigg, Homer L
    Knox, Kenneth
    Erickson, Heidi E
    Weinkauf, Craig C
    Bime, Christian
    Bixby, Billie A
    Parthasarathy, Sairam
    Mosier, Jarrod M
    LaFleur, Bonnie J
    Bhattacharya, Deepta
    Nikolich, Janko Z
    Show allShow less
    Affiliation
    Department of Immunobiology, University of Arizona College of Medicine-Tucson
    Arizona Center on Aging, University of Arizona College of Medicine-Tucson
    Department of Medicine, University of Arizona College of Medicine-Phoenix
    Division of Vascular Surgery, University of Arizona
    Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, University of Arizona College of Medicine Tucson
    Department of Emergency Medicine, University of Arizona College of Medicine Tucson
    BIO5 Institute, University of Arizona
    R. Ken Coit College of Pharmacy, University of Arizona
    Issue Date
    2023-01-12
    Keywords
    COVID-19
    Lymphocytes
    Reticulocytes
    Severity
    T-cells
    
    Metadata
    Show full item record
    Publisher
    Springer Science and Business Media Deutschland GmbH
    Citation
    Jergović, M., Watanabe, M., Bhat, R., Coplen, C. P., Sonar, S. A., Wong, R., Castaneda, Y., Davidson, L., Kala, M., Wilson, R. C., Twigg, H. L., III, Knox, K., Erickson, H. E., Weinkauf, C. C., Bime, C., Bixby, B. A., Parthasarathy, S., Mosier, J. M., LaFleur, B. J., … Nikolich, J. Z. (2023). T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults. GeroScience.
    Journal
    GeroScience
    Rights
    © 2023. The Author(s), under exclusive licence to American Aging Association.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common cold. Disease severity increases with age starting at 30 and reaches astounding mortality rates that are ~330 fold higher in persons above 85 years of age compared to those 18–39 years old. To understand age-specific immune pathobiology of COVID-19, we have analyzed soluble mediators, cellular phenotypes, and transcriptome from over 80 COVID-19 patients of varying ages and disease severity, carefully controlling for age as a variable. We found that reticulocyte numbers and peripheral blood transcriptional signatures robustly correlated with disease severity. By contrast, decreased numbers and proportion of naïve T-cells, reported previously as a COVID-19 severity risk factor, were found to be general features of aging and not of COVID-19 severity, as they readily occurred in older participants experiencing only mild or no disease at all. Single-cell transcriptional signatures across age and severity groups showed that severe but not moderate/mild COVID-19 causes cell stress response in different T-cell populations, and some of that stress was unique to old severe participants, suggesting that in severe disease of older adults, these defenders of the organism may be disabled from performing immune protection. These findings shed new light on interactions between age and disease severity in COVID-19.
    Note
    No embargo COVID-19
    EISSN
    2509-2723
    PubMed ID
    36633825
    DOI
    10.1007/s11357-022-00724-y
    Version
    Final accepted manuscript
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11357-022-00724-y
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults.
    • Authors: Jergović M, Watanabe M, Bhat R, Coplen CP, Sonar SA, Wong R, Castaneda Y, Davidson L, Kala M, Wilson RC, Twigg HL 3rd, Knox K, Erickson HE, Weinkauf CC, Bime C, Bixby BA, Parthasarathy S, Mosier JM, LaFleur BJ, Bhattacharya D, Nikolich JŽ
    • Issue date: 2022 Dec 22
    • Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People.
    • Authors: Demaret J, Corroyer-Simovic B, Alidjinou EK, Goffard A, Trauet J, Miczek S, Vuotto F, Dendooven A, Huvent-Grelle D, Podvin J, Dreuil D, Faure K, Deplanque D, Bocket L, Duhamel A, Labreuche J, Sobaszek A, Hisbergues M, Puisieux F, Labalette M, Lefèvre G
    • Issue date: 2021
    • T cell receptor β repertoires in patients with COVID-19 reveal disease severity signatures.
    • Authors: Xu J, Li XX, Yuan N, Li C, Yang JG, Cheng LM, Lu ZX, Hou HY, Zhang B, Hu H, Qian Y, Liu XX, Li GC, Wang YD, Chu M, Dong CR, Liu F, Ge QG, Yang YJ
    • Issue date: 2023
    • Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns.
    • Authors: Christensen EE, Jørgensen MJ, Nore KG, Dahl TB, Yang K, Ranheim T, Huse C, Lind A, Nur S, Stiksrud B, Jenum S, Tonby K, Holter JC, Holten AR, Halvorsen B, Dyrhol-Riise AM
    • Issue date: 2021 Sep
    • Antibody and cellular immune responses following dual COVID-19 vaccination within infection-naive residents of long-term care facilities: an observational cohort study.
    • Authors: Tut G, Lancaster T, Sylla P, Butler MS, Kaur N, Spalkova E, Bentley C, Amin U, Jadir A, Hulme S, Ayodele M, Bone D, Tut E, Bruton R, Krutikov M, Giddings R, Shrotri M, Azmi B, Fuller C, Baynton V, Irwin-Singer A, Hayward A, Copas A, Shallcross L, Moss P
    • Issue date: 2022 Jul
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.