Investigations of Small Molecules for Their Use in Alzheimer’s Disease, Colorectal Cancer, and Fluorescent Studies

Abstract

The research discussed in this dissertation is concentrated on the knowledge-based investigation into structure-activity relationships between small molecules and the resultant effects on kinase inhibition and pharmacokinetics. The medicinal chemistry approaches that optimize these relationships for their use in targeted kinase inhibitors including DYRK and CLK, and Wnt signaling inhibition for a variety of therapeutic uses such as Alzheimer’s disease and colorectal cancer. Lastly, the systematic study and tuning of efficiently synthesized fluorogenic probes through multicomponent reactions. To this end, this thesis combines work done to improve the pharmacological profiles of small-molecule CMGC kinase inhibitors and the investigations of economical fluorophores.