Role of MAPK Dynamics in Movement and Survival

Abstract

Extracellular signal regulated kinases (ERK) are a type of kinase that regulates cellular responses to extracellular signals. This study examines their participation in dynamic behaviors as a response to apoptosis within the colon epithelium. This study is conducted within a 2D organoid monolayer that contains distinct proliferative and differentiated zones. ERK activation emanated from the site of apoptotic cells in a wave, which is similar to the difference between crypt formations within the organoid. When ERK expression is disrupted through inhibition or activation, the patterning of the epithelium is lost. This study thus sheds light on the factors leading to the maintenance of the epithelium.