Hyperexcitability in Prodromal Alzheimer’s Disease and Mild Cognitive Impairment: Resting Motor Threshold as a Potential Biomarker
Issue Date
2023Keywords
Alzheimer's diseasebiomarker
Mild cognitive impairment
motor threshold
neuronal excitability
Transcranial magnetic stimulation
Advisor
Chou, Ying-hui
Metadata
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The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
A shift from focusing on structural to functional changes in prodromal Alzheimer’s disease (AD) and Mild Cognitive Impairment (MCI) may be necessary to elucidate the underlying initiation of cognitive decline. Utilizing transcranial magnetic stimulation (TMS) as a technique to explore changes in the balance of excitation and inhibition in MCI can be useful for understanding how changes in excitability affect cognition. This paper uses resting motor threshold (rMT) as a measure of excitability and investigates the relationship with the memory, attention, and verbal domains of cognition. As excitability increases, cognition is expected to decrease. The findings of this study showed that memory level was predictive of rMT, but attention and verbal domains were not. This suggests that rMT may be a better reflection of memory deficits specifically.Type
Electronic Thesistext
Degree Name
M.S.Degree Level
mastersDegree Program
Graduate CollegeClinical Translational Sciences