Show simple item record

dc.contributor.advisorCook, Sarah
dc.contributor.authorAntoniou, Victoria
dc.creatorAntoniou, Victoria
dc.date.accessioned2023-08-17T04:31:19Z
dc.date.available2023-08-17T04:31:19Z
dc.date.issued2023
dc.identifier.citationAntoniou, Victoria. (2023). THE RELATIONSHIP BETWEEN DEFAULT MODE HYPERACTIVITY, DECISION MAKING, AND DEPRESSION AND ADHD (Bachelor's thesis, University of Arizona, Tucson, USA).
dc.identifier.urihttp://hdl.handle.net/10150/668538
dc.description.abstractThe default mode network (DMN) is a neural network involved in many cognitive processes, one being decision making. When the DMN is not properly suppressed by the task-positive network (TPN), such as in ADHD and depression, this can lead to hyperactivity of the DMN. Decision making is also impaired in ADHD and depression, which begs the question: how does hyperactivity of the default mode network affect decision making in disorders such as depression and ADHD? This review focuses on perceptual decision making, explore-exploit decision making, and temporal decision making to answer this question. ADHD subjects displayed reduced DMN functional connectivity between the DMN and TPN, possibly due to dysmaturation of their connectivity in adolescence, which was associated with worse performance on temporal discounting tasks and was significantly correlated with delay aversion. Major depressive disorder (MDD) subjects exhibited increased risk-averse behavior and stronger functional connectivity of the posterior cingulate cortex (PCC) and precuneus lobule (PCUN), which is indicative of DMN hyperactivity. Furthermore, the medial prefrontal cortex (mPFC) plays a role in both emotional and explore exploit decision making. Overall, it was concluded that DMN hyperactivity in ADHD and depression was correlated with impaired decision making. These results could be used to improve upon treatment options for ADHD and depression.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subject
dc.titleTHE RELATIONSHIP BETWEEN DEFAULT MODE HYPERACTIVITY, DECISION MAKING, AND DEPRESSION AND ADHD
dc.typeElectronic thesis
dc.typetext
thesis.degree.grantorUniversity of Arizona
thesis.degree.levelbachelors
thesis.degree.disciplineNeuroscience and Cognitive Science
thesis.degree.disciplineHonors College
thesis.degree.nameB.S.
refterms.dateFOA2023-08-17T04:31:19Z


Files in this item

Thumbnail
Name:
azu_etd_hr_2023_0010_sip1_m.pdf
Size:
1.962Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record