PublisherThe University of Arizona.
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AbstractSystemic lupus erythematosus (SLE) is an autoimmune disorder with no cure. In order to develop potential treatments, it is important to understand the molecular pathogenesis of the disease. Using a mouse model developed in our lab with a single nucleotide polymorphism (SNP) in the Msh6 gene, we were curious if environmental factors that are associated with SLE would exacerbate its SLE-like phenotype. Patientswith SLE have increased sun sensitivity leading us to explore the effects of ultraviolet B (UVB) light on the MSH6 mouse model. It was found that MSH6 variant mice had a prolonged immunosuppression as compared to their wildtype counterparts after UVB exposure. This points us in future directions exploring the effects of environmental factors, like sunlight, on SLE phenotypes
Degree ProgramPhysiology and Medical Sciences