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dc.contributor.authorSong, Shang
dc.contributor.authorMcConnell, Kelly W.
dc.contributor.authorShan, Dingying
dc.contributor.authorChen, Cheng
dc.contributor.authorOh, Byeongtaek
dc.contributor.authorSun, Jindi
dc.contributor.authorPoon, Ada S. Y.
dc.contributor.authorGeorge, Paul M.
dc.date.accessioned2024-03-13T18:12:22Z
dc.date.available2024-03-13T18:12:22Z
dc.date.issued2024-01-25
dc.identifier.citationSong, S., McConnell, K. W., Shan, D., Chen, C., Oh, B., Sun, J., ... & George, P. M. (2024). Conductive gradient hydrogels allow spatial control of adult stem cell fate. Journal of Materials Chemistry B, 12(7), 1854-1863.en_US
dc.identifier.issn2050-750X
dc.identifier.doi10.1039/d3tb02269b
dc.identifier.urihttp://hdl.handle.net/10150/671229
dc.description.abstractElectrical gradients are fundamental to physiological processes including cell migration, tissue formation, organ development, and response to injury and regeneration. Current electrical modulation of cells is primarily studied under a uniform electrical field. Here we demonstrate the fabrication of conductive gradient hydrogels (CGGs) that display mechanical properties and varying local electrical gradients mimicking physiological conditions. The electrically-stimulated CGGs enhanced human mesenchymal stem cell (hMSC) viability and attachment. Cells on CGGs under electrical stimulation showed a high expression of neural progenitor markers such as Nestin, GFAP, and Sox2. More importantly, CGGs showed cell differentiation toward oligodendrocyte lineage (Oligo2) in the center of the scaffold where the electric field was uniform with a greater intensity, while cells preferred neuronal lineage (NeuN) on the edge of the scaffold on a varying electric field at lower magnitude. Our data suggest that CGGs can serve as a useful platform to study the effects of electrical gradients on stem cells and potentially provide insights on developing new neural engineering applications.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.rights© 2024 The Royal Society of Chemistry.en_US
dc.rights.urihttps://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectGeneral Materials Scienceen_US
dc.subjectBiomedical Engineeringen_US
dc.subjectGeneral Chemistryen_US
dc.subjectGeneral Medicineen_US
dc.titleConductive gradient hydrogels allow spatial control of adult stem cell fateen_US
dc.typeArticleen_US
dc.identifier.eissn2050-7518
dc.contributor.departmentDepartments of Neuroscience GIDP, Materials Science and Engineering, BIO5 Institute, The University of Arizonaen_US
dc.contributor.departmentDepartment of Biomedical Engineering, The University of Arizonaen_US
dc.identifier.journalJournal of Materials Chemistry Ben_US
dc.description.note12 month embargo; first published 25 January 2024en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of Materials Chemistry B
dc.source.volume12
dc.source.issue7
dc.source.beginpage1854
dc.source.endpage1863


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