Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Ozonoff, A.; Jayavelu, N.D.; Liu, S.; Melamed, E.; Milliren, C.E.; Qi, J.; Geng, L.N.; McComsey, G.A.; Cairns, C.B.; Baden, L.R.; Schaenman, J.; Shaw, A.C.; Samaha, H.; Seyfert-Margolis, V.; Krammer, F.; Rosen, L.B.; Steen, H.; Syphurs, C.; Dandekar, R.; Shannon, C.P.; Sekaly, R.P.; Ehrlich, L.I.R.; Corry, D.B.; Kheradmand, F.; Atkinson, M.A.; Brakenridge, S.C.; Higuita, N.I.A.; Metcalf, J.P.; Hough, C.L.; Messer, W.B.; Pulendran, B.; Nadeau, K.C.; Davis, M.M.; Sesma, A.F.; Simon, V.; van Bakel, H.; Kim-Schulze, S.; Hafler, D.A.; Levy, O.; Kraft, M.; Bime, C.; Haddad, E.K.; Calfee, C.S.; Erle, D.J.; Langelier, C.R.; Eckalbar, W.; Bosinger, S.E.; Peters, B.; Kleinstein, S.H.; Reed, E.F.; Augustine, A.D.; Diray-Arce, J.; Maecker, H.T.; Altman, M.C.; Montgomery, R.R.; Becker, P.M.; Rouphael, N.

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University of Arizona

Issue Date

2024-01-03

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Nature Research

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Ozonoff, A., Jayavelu, N.D., Liu, S. et al. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nat Commun 15, 216 (2024). https://doi.org/10.1038/s41467-023-44090-5

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Nature Communications

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This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.

Abstract

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC. © 2024, The Author(s).

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Open access journal

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2041-1723

PubMed ID

38172101

DOI

10.1038/s41467-023-44090-5

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Final Published Version

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UA Faculty Publications

© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.

Except where otherwise noted, this item's license is described as © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License.