No Evidence That Analgesic Use after COVID-19 Vaccination Negatively Impacts Antibody Responses
dc.contributor.author | Lafleur, B.J. | |
dc.contributor.author | White, L. | |
dc.contributor.author | Dake, M.D. | |
dc.contributor.author | Nikolich, J.Z. | |
dc.contributor.author | Sprissler, R. | |
dc.contributor.author | Bhattacharya, D. | |
dc.date.accessioned | 2024-03-26T06:52:01Z | |
dc.date.available | 2024-03-26T06:52:01Z | |
dc.date.issued | 2023-12-12 | |
dc.identifier.citation | Bonnie J. Lafleur, Lisa White, Michael D. Dake, Janko Z. Nikolich, Ryan Sprissler, Deepta Bhattacharya; No Evidence That Analgesic Use after COVID-19 Vaccination Negatively Impacts Antibody Responses. Immunohorizons 1 December 2023; 7 (12): 834–841. https://doi.org/10.4049/immunohorizons.2300090 | |
dc.identifier.issn | 2573-7732 | |
dc.identifier.pmid | 38085168 | |
dc.identifier.doi | 10.4049/immunohorizons.2300090 | |
dc.identifier.uri | http://hdl.handle.net/10150/671885 | |
dc.description.abstract | Uptake of mRNA vaccines, especially booster immunizations, against COVID-19 has been lower than hoped, perhaps in part due to their reactogenicity. Analgesics might alleviate symptoms associated with vaccination, but they might also impact immune responses. We semiquantitatively measured Ab responses following COVID-19 vaccination in 2354 human participants surveyed about analgesic use after vaccination. Participants who used nonsteroidal anti-inflammatory drugs or acetaminophen after vaccination showed elevated Ab levels against the receptor-binding domain of Spike protein relative to those who did not use analgesics. This pattern was observed for both mRNA-1273 and BNT162b2 and across age groups. Participants who used analgesics more frequently reported fatigue, muscle aches, and headaches than did those who did not use painkillers. Among participants who reported these symptoms, we observed no statistically significant differences in Ab levels irrespective of analgesic use. These data suggest that elevated Ab levels are associated with symptoms and inflammatory processes rather than painkiller use per se. Taken together, we find no evidence that analgesic use reduces Ab responses after COVID-19 vaccination. Recommendation of their use to alleviate symptoms might improve uptake of booster immunizations. Copyright © 2023 The Authors. | |
dc.language.iso | en | |
dc.publisher | American Association of Immunologists | |
dc.rights | © 2023 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | No Evidence That Analgesic Use after COVID-19 Vaccination Negatively Impacts Antibody Responses | |
dc.type | Article | |
dc.type | text | |
dc.contributor.department | BIO5 Institute, University of Arizona | |
dc.contributor.department | Department of Pharmacy Practice and Science, R. Ken Coit College of Pharmacy, University of Arizona | |
dc.contributor.department | Health Sciences, University of Arizona | |
dc.contributor.department | Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ | |
dc.contributor.department | University of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ | |
dc.contributor.department | University of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core | |
dc.contributor.department | Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, United States | |
dc.contributor.department | Department of Surgery, University of Arizona College of Medicine | |
dc.identifier.journal | ImmunoHorizons | |
dc.description.note | Open access journal | |
dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | |
dc.eprint.version | Final Published Version | |
dc.source.journaltitle | ImmunoHorizons | |
refterms.dateFOA | 2024-03-26T06:52:01Z |