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dc.contributor.authorLafleur, B.J.
dc.contributor.authorWhite, L.
dc.contributor.authorDake, M.D.
dc.contributor.authorNikolich, J.Z.
dc.contributor.authorSprissler, R.
dc.contributor.authorBhattacharya, D.
dc.date.accessioned2024-03-26T06:52:01Z
dc.date.available2024-03-26T06:52:01Z
dc.date.issued2023-12-12
dc.identifier.citationBonnie J. Lafleur, Lisa White, Michael D. Dake, Janko Z. Nikolich, Ryan Sprissler, Deepta Bhattacharya; No Evidence That Analgesic Use after COVID-19 Vaccination Negatively Impacts Antibody Responses. Immunohorizons 1 December 2023; 7 (12): 834–841. https://doi.org/10.4049/immunohorizons.2300090
dc.identifier.issn2573-7732
dc.identifier.pmid38085168
dc.identifier.doi10.4049/immunohorizons.2300090
dc.identifier.urihttp://hdl.handle.net/10150/671885
dc.description.abstractUptake of mRNA vaccines, especially booster immunizations, against COVID-19 has been lower than hoped, perhaps in part due to their reactogenicity. Analgesics might alleviate symptoms associated with vaccination, but they might also impact immune responses. We semiquantitatively measured Ab responses following COVID-19 vaccination in 2354 human participants surveyed about analgesic use after vaccination. Participants who used nonsteroidal anti-inflammatory drugs or acetaminophen after vaccination showed elevated Ab levels against the receptor-binding domain of Spike protein relative to those who did not use analgesics. This pattern was observed for both mRNA-1273 and BNT162b2 and across age groups. Participants who used analgesics more frequently reported fatigue, muscle aches, and headaches than did those who did not use painkillers. Among participants who reported these symptoms, we observed no statistically significant differences in Ab levels irrespective of analgesic use. These data suggest that elevated Ab levels are associated with symptoms and inflammatory processes rather than painkiller use per se. Taken together, we find no evidence that analgesic use reduces Ab responses after COVID-19 vaccination. Recommendation of their use to alleviate symptoms might improve uptake of booster immunizations. Copyright © 2023 The Authors.
dc.language.isoen
dc.publisherAmerican Association of Immunologists
dc.rights© 2023 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleNo Evidence That Analgesic Use after COVID-19 Vaccination Negatively Impacts Antibody Responses
dc.typeArticle
dc.typetext
dc.contributor.departmentBIO5 Institute, University of Arizona
dc.contributor.departmentDepartment of Pharmacy Practice and Science, R. Ken Coit College of Pharmacy, University of Arizona
dc.contributor.departmentHealth Sciences, University of Arizona
dc.contributor.departmentDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ
dc.contributor.departmentUniversity of Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ
dc.contributor.departmentUniversity of Arizona Genomics Core and the Arizona Research Labs, University of Arizona Genetics Core
dc.contributor.departmentDepartment of Immunobiology, University of Arizona College of Medicine, Tucson, AZ, United States
dc.contributor.departmentDepartment of Surgery, University of Arizona College of Medicine
dc.identifier.journalImmunoHorizons
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal Published Version
dc.source.journaltitleImmunoHorizons
refterms.dateFOA2024-03-26T06:52:01Z


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© 2023 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.
Except where otherwise noted, this item's license is described as © 2023 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.