• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Elucidating the Therapeutic Effects of Individual Compounds Found in Cannabis Sativa for Pain Management and Reward Liability

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_21254_sip1_m.pdf
    Size:
    6.222Mb
    Format:
    PDF
    Download
    Author
    Schwarz, Abigail Margaret
    Issue Date
    2024
    Keywords
    Addiction
    Adenosine A2a Receptor
    Cannabis
    Chronic Pain
    Reward
    Advisor
    Streicher, John M.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The Cannabis plant contains over 550 different chemicals, many of which are bioactive and understudied. Despite the complexity of Cannabis pharmacology, most work has investigated the primary phytocannabinoids cannabidiol (CBD) and Δ9 tetrahydrocannabinol (Δ9 THC). With increased public access to Cannabis and its constituents, as well as evidence for its efficacy for therapeutic uses, it is essential to investigate the individual compounds of Cannabis to determine their therapeutic effects as well as adverse side effects. In this dissertation, I outline the impact of different classes of chemicals from Cannabis and their effects on neuropathic pain, potential side effects, and select compounds for assessing impacts in opioid use disorder. These classes of chemicals include terpenes (linalool, geraniol, β-pinene, α-humulene, and β-caryophyllene) and phytocannabinoids (cannabinol, cannabidivarin, cannabigerol, Δ9 tetrahydrocannabivarin, Δ8 tetrahydrocannabinol, and Δ9 tetrahydrocannabinolic acid) with some investigation into the mechanism of blends of different terpenes from distinct Cannabis chemovars. I hope the work presented contributes to our collective knowledge of Cannabis as a therapeutic agent and can improve Cannabis-based therapies.
    Type
    Electronic Dissertation
    text
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Neuroscience
    Degree Grantor
    University of Arizona
    Collections
    Dissertations

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.