Emerging role for interferons in respiratory viral infections and childhood asthma
dc.contributor.author | Bosco, A. | |
dc.date.accessioned | 2024-08-05T02:53:55Z | |
dc.date.available | 2024-08-05T02:53:55Z | |
dc.date.issued | 2023-02-20 | |
dc.identifier.citation | Bosco A (2023) Emerging role for interferons in respiratory viral infections and childhood asthma. Front. Immunol. 14:1109001. doi: 10.3389/fimmu.2023.1109001 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.pmid | 36895568 | |
dc.identifier.doi | 10.3389/fimmu.2023.1109001 | |
dc.identifier.uri | http://hdl.handle.net/10150/673610 | |
dc.description.abstract | Respiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Decades of research has focused on the role of type I interferons in antiviral immunity and ensuing airway diseases, however, recent findings have highlighted several novel aspects of the interferon response that merit further investigation. In this perspective, we discuss emerging roles of type I interferons in the pathogenesis of sLRI in children. We propose that variations in interferon response patterns exist as discrete endotypes, which operate locally in the airways and systemically through a lung-blood-bone marrow axis. We discuss new insights into the role of interferons in immune training, bacterial lysate immunotherapy, and allergen-specific immunotherapy. Interferons play complex and diverse roles in the pathogenesis of sLRI and later asthma, providing new directions for mechanistic studies and drug development. Copyright © 2023 Bosco. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | © 2023 Bosco. This is an open-access article distributed under the terms of the Creative Commons Attribution License. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | childhood asthma | |
dc.subject | innate immunity | |
dc.subject | interferons | |
dc.subject | respiratory syncytial virus | |
dc.subject | rhinovirus | |
dc.subject | systems biology | |
dc.subject | trained immunity | |
dc.title | Emerging role for interferons in respiratory viral infections and childhood asthma | |
dc.type | Article | |
dc.type | text | |
dc.contributor.department | Asthma and Airway Disease Research Center, University of Arizona | |
dc.contributor.department | Department of Immunobiology, The University of Arizona College of Medicine | |
dc.identifier.journal | Frontiers in Immunology | |
dc.description.note | Open access journal | |
dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | |
dc.eprint.version | Final Published Version | |
dc.source.journaltitle | Frontiers in Immunology | |
refterms.dateFOA | 2024-08-05T02:53:55Z |