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dc.contributor.authorBosco, A.
dc.date.accessioned2024-08-05T02:53:55Z
dc.date.available2024-08-05T02:53:55Z
dc.date.issued2023-02-20
dc.identifier.citationBosco A (2023) Emerging role for interferons in respiratory viral infections and childhood asthma. Front. Immunol. 14:1109001. doi: 10.3389/fimmu.2023.1109001
dc.identifier.issn1664-3224
dc.identifier.pmid36895568
dc.identifier.doi10.3389/fimmu.2023.1109001
dc.identifier.urihttp://hdl.handle.net/10150/673610
dc.description.abstractRespiratory syncytial virus (RSV) and Rhinovirus (RV) infections are major triggers of severe lower respiratory illnesses (sLRI) in infants and children and are strongly associated with the subsequent development of asthma. Decades of research has focused on the role of type I interferons in antiviral immunity and ensuing airway diseases, however, recent findings have highlighted several novel aspects of the interferon response that merit further investigation. In this perspective, we discuss emerging roles of type I interferons in the pathogenesis of sLRI in children. We propose that variations in interferon response patterns exist as discrete endotypes, which operate locally in the airways and systemically through a lung-blood-bone marrow axis. We discuss new insights into the role of interferons in immune training, bacterial lysate immunotherapy, and allergen-specific immunotherapy. Interferons play complex and diverse roles in the pathogenesis of sLRI and later asthma, providing new directions for mechanistic studies and drug development. Copyright © 2023 Bosco.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.rights© 2023 Bosco. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectchildhood asthma
dc.subjectinnate immunity
dc.subjectinterferons
dc.subjectrespiratory syncytial virus
dc.subjectrhinovirus
dc.subjectsystems biology
dc.subjecttrained immunity
dc.titleEmerging role for interferons in respiratory viral infections and childhood asthma
dc.typeArticle
dc.typetext
dc.contributor.departmentAsthma and Airway Disease Research Center, University of Arizona
dc.contributor.departmentDepartment of Immunobiology, The University of Arizona College of Medicine
dc.identifier.journalFrontiers in Immunology
dc.description.noteOpen access journal
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal Published Version
dc.source.journaltitleFrontiers in Immunology
refterms.dateFOA2024-08-05T02:53:55Z


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© 2023 Bosco. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © 2023 Bosco. This is an open-access article distributed under the terms of the Creative Commons Attribution License.