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dc.contributor.authorLarson, E.J.
dc.contributor.authorPergande, M.R.
dc.contributor.authorMoss, M.E.
dc.contributor.authorRossler, K.J.
dc.contributor.authorWenger, R.K.
dc.contributor.authorKrichel, B.
dc.contributor.authorJosyer, H.
dc.contributor.authorMelby, J.A.
dc.contributor.authorRoberts, D.S.
dc.contributor.authorPike, K.
dc.contributor.authorShi, Z.
dc.contributor.authorChan, H.-J.
dc.contributor.authorKnight, B.
dc.contributor.authorRogers, H.T.
dc.contributor.authorBrown, K.A.
dc.contributor.authorOng, I.M.
dc.contributor.authorJeong, K.
dc.contributor.authorMarty, M.T.
dc.contributor.authorMcIlwain, S.J.
dc.contributor.authorGe, Y.
dc.date.accessioned2024-08-09T00:15:17Z
dc.date.available2024-08-09T00:15:17Z
dc.date.issued2023-06-09
dc.identifier.citationEli J Larson, Melissa R Pergande, Michelle E Moss, Kalina J Rossler, R Kent Wenger, Boris Krichel, Harini Josyer, Jake A Melby, David S Roberts, Kyndalanne Pike, Zhuoxin Shi, Hsin-Ju Chan, Bridget Knight, Holden T Rogers, Kyle A Brown, Irene M Ong, Kyowon Jeong, Michael T Marty, Sean J McIlwain, Ying Ge, MASH Native: a unified solution for native top-down proteomics data processing, Bioinformatics, Volume 39, Issue 6, June 2023, btad359, https://doi.org/10.1093/bioinformatics/btad359
dc.identifier.issn1367-4803
dc.identifier.pmid37294807
dc.identifier.doi10.1093/bioinformatics/btad359
dc.identifier.urihttp://hdl.handle.net/10150/674014
dc.description.abstractMotivation: Native top-down proteomics (nTDP) integrates native mass spectrometry (nMS) with top-down proteomics (TDP) to provide comprehensive analysis of protein complexes together with proteoform identification and characterization. Despite significant advances in nMS and TDP software developments, a unified and user-friendly software package for analysis of nTDP data remains lacking. Results: We have developed MASH Native to provide a unified solution for nTDP to process complex datasets with database searching capabilities in a user-friendly interface. MASH Native supports various data formats and incorporates multiple options for deconvolution, database searching, and spectral summing to provide a “one-stop shop” for characterizing both native protein complexes and proteoforms. Availability and implementation: The MASH Native app, video tutorials, written tutorials, and additional documentation are freely available for download at https://labs.wisc.edu/gelab/MASH_Explorer/MASHSoftware.php. All data files shown in user tutorials are included with the MASH Native software in the download .zip file. ©The Author(s) 2023. Published by Oxford University Press.
dc.language.isoen
dc.publisherOxford University Press
dc.rights© The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMASH Native: a unified solution for native top-down proteomics data processing
dc.typeArticle
dc.typetext
dc.contributor.departmentDepartment of Chemistry and Biochemistry, University of Arizona
dc.identifier.journalBioinformatics
dc.description.noteOpen access article
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
dc.eprint.versionFinal Published Version
dc.source.journaltitleBioinformatics
refterms.dateFOA2024-08-09T00:15:17Z


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© The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © The Author(s) 2023. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).