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dc.contributor.authorHarel, Keren
dc.contributor.authorCzamanski-Cohen, Johanna
dc.contributor.authorCohen, Miri
dc.contributor.authorLane, Richard D.
dc.contributor.authorDines, Monica
dc.contributor.authorCaspi, Opher
dc.contributor.authorWeihs, Karen L.
dc.date.accessioned2024-12-15T01:53:22Z
dc.date.available2024-12-15T01:53:22Z
dc.date.issued2024-12
dc.identifier.citationHarel, K., Czamanski-Cohen, J., Cohen, M., Lane, R.D., Dines, M., Caspi, O., Weihs, K.L., Differences in emotional awareness moderate Cytokine-Symptom associations among breast cancer survivors, Brain, Behavior, and Immunity (2024), doi: https://doi.org/10.1016/j.bbi.2024.12.005en_US
dc.identifier.issn0889-1591
dc.identifier.doi10.1016/j.bbi.2024.12.005
dc.identifier.urihttp://hdl.handle.net/10150/675365
dc.description.abstractCancer survivors have elevated levels of proinflammatory cytokines, which could be associated with cancer-related symptoms. Given that proinflammatory cytokines heighten negative affect by directly affecting the brain, we explored these direct associations and whether differences in levels of emotional awareness moderate the associations between proinflammatory cytokines and cancer-related symptoms. This cross-sectional, secondary analysis of baseline data was collected from 162 female breast cancer survivors (aged 36–70 years), who were enrolled 6± 4 months after completing cancer treatment. We tested cytokines in serum (IL-1β, IL-6, IL-8, TNF-α, IL-4, IL-10, and TGF-β) and assessed depression, cancer-related fatigue, pain intensity, and pain interference. Emotional awareness was assessed using a performance measure, the Levels of Emotional Awareness Scale. In participants with high but not average or low levels of emotional awareness, positive associations were found for IL-1β, IL-6, and TNF-α with depression and between IL-6 and TNF-α with pain intensity. In addition, IL-6 had a positive association with pain intensity at average levels of emotional awareness. These results suggest that women with high or in some cases average, but not low, emotional awareness reported depression and pain as being positively associated with their cytokine levels. By using emotional awareness as a cognitive resource to promote emotion regulation and distress transformation, interventions may be able to counteract heightened sensitivity to the mood-altering effects of cytokines.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.rights© 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subjectbreast cancer survivoren_US
dc.subjectemotional awarenessen_US
dc.subjectcytokineen_US
dc.subjectproinflammatory cytokineen_US
dc.subjectcancer-related symptomen_US
dc.subjectdepressionen_US
dc.subjectfatigueen_US
dc.subjectpain intensityen_US
dc.subjectpain interferenceen_US
dc.titleDifferences in emotional awareness moderate Cytokine-Symptom associations among breast cancer survivorsen_US
dc.typeArticleen_US
dc.contributor.departmentDepartment of Psychiatry, University of Arizonaen_US
dc.contributor.departmentArizona Cancer Center, University of Arizonaen_US
dc.identifier.journalBrain, Behavior, and Immunityen_US
dc.description.note12 month embargo; Available online 12 December 2024.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.identifier.piiS0889159124007347
dc.source.journaltitleBrain, Behavior, and Immunity


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