The Role of Long Intergenic Non-Coding RNA00867 in Fetal Development
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
LincRNAs are increasingly recognized as key regulators of development. This study examined the role of lincRNA00867 using a cre-loxP mouse model. Floxed and heterozygous lincRNA09867 mice were viable and exhibited normal pregnancy progression, offspring growth, blood glucose, and blood pressure profiles. However, no homozygous knockout (lincRNA00867–/–) pups were recovered, and genotyping at embryonic stages confirmed embryonic lethality. Tissue expression analysis revealed that lincRNA00867 is predominantly expressed in the testes. These findings demonstrate that lincRNA00867 is essential for embryonic viability and may play a specialized role in reproductive development.Type
textElectronic Thesis
Degree Name
M.S.Degree Level
mastersDegree Program
Graduate CollegeAnimal Sciences