DEVELOPMENT OF A BIOCOMPATIBLE AND BIODEGRADABLE CHITOSAN-GELATIN SCAFFOLD CROSSLINKED TO ENHANCE WOUND HEALING AND ANTIMICROBIAL ACTIVITY

Abstract

Traditional bandages and gauze are widely used in medical applications but suffer from significant limitations, including poor biocompatibility and the absence of properties that would aid in wound healing. This study proposes the development of a chitosan-gelatin scaffold crosslinked with genipin to address these shortcomings. The resulting scaffold is designed to be biodegradable and biocompatible while offering antibacterial, hemostatic, anti-inflammatory, and antifungal properties, all of which are critical for enhancing wound healing and promoting tissue regeneration. Although no experimental data have been collected, this proposal is based on an extensive review of studies involving chitosan, gelatin, crosslinking agents, and related scaffolds, culminating in a detailed procedural framework for future research and development.